摘要
目的:观察T细胞分化蛋白2(Mal2)在肝细胞癌(HCC)中的表达并探讨其临床意义。方法:采用免疫组织化学染色方法检测226例HCC患者的肿瘤组织和86例正常肝组织中Mal2蛋白的表达情况,并分析其与HCC临床病理指标的关系。通过生存分析比较不同Mal2表达水平患者的生存情况,并分析影响HCC患者生存情况的危险因素。结果:Mal2蛋白在HCC肿瘤组织中的表达水平显著高于正常肝组织(P<0.05)。Mal2蛋白表达水平增高与HCC患者血管侵犯、淋巴结转移和较高的TNM分期相关。生存分析表明Mal2蛋白高表达组患者术后生存率显著低于低表达组患者(P<0.05)。Mal2阳性表达、血管癌栓形成、淋巴结转移及较高的TNM分期是影响HCC患者术后生存时间的独立危险因素。结论:Mal2蛋白在HCC组织中呈过表达趋势,且与肿瘤转移密切相关,可能在HCC的诊断与预后判断中有一定的应用价值。
Objective： To determine the expression and clinical significance of Mal, T-cell differentiation protein 2 （Mal2） in hepatocellular carcinoma （HCC）. Methods： The expressions of Mal2 protein in 226 cases of liver cancer tissue and 86 cases of normal liver tissue were examined by immunohistochemistry. The relationship between Mal2 and clinical pathological index was analyzed. The survival rate was compared by survival analysis between the different expression of Mal2 protein in HCC patients, and the risk factors of survival were determined. Results： The expression of Mal2 protein in HCC tissue was significantly higher than that in the normal liver tissues （P〈0.05）. The increased expression of Mal2 protein had closely relationship with vascular invasion, lymph node metastasis and advanced TNM stage. The post-operation survival rate of patients with higher Mal2 expression was worse than the patients with lower Male2 expression （P〈0.05）. The positive expression of Mal2, vascular invasion, lymph node metastasis and advanced TNM stage were the independent risk factors of the survival time of HCC patients. Conclusions： Mal2 protein was over-expressed in HCC tissue, and was closely related to the tumor metastasis, it was probably had good potential application in the diagnosis and prognosis of HCC.
出处
《现代生物医学进展》
CAS
2016年第14期2670-2675,共6页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81201926)
关键词
肝细胞癌
T细胞分化蛋白2
生存时间
预后
Hepatocellular carcinoma
T-cell differentiation protein 2
Survival time
Prognosis
