摘要
目的:探讨化疗致肺癌患者严重粒细胞减少的相关危险因素,为临床用药提供参考。方法:回顾性分析肺癌患者临床资料,统计分析找出与严重粒细胞减少有关的危险因素。结果:单因素分析显示严重粒细胞减少与放疗史、化疗周期和粒细胞集落因子使用时机具有相关性。Logistic回归分析显示,放疗史、粒细胞集落因子使用时机是肺癌患者严重粒细胞减少的危险因素。结论:对于有放疗史的患者,可选用细胞毒性小的化疗方案,或降低药物剂量,或预防使用集落刺激因子;合理应用粒细胞集落刺激因子可减轻肺癌化疗引起的严重粒细胞减少。
Objective：To discuss the risk factors in lung cancer patients with chemotherapy-induced severe neutropenia to provide reference for clinical drug use.Methods：A retrospective analysis was performed for the patients with lung cancer,and the risk factors of severe neutropenia were statistically analyzed and found out.Results：The results of single factor experiments showed that the incidence of severe neutropenia was related with radiotherapy history,cycles of chemotherapy and the use time of granulocyte colony factor.Based on a binary logistic regression analysis,the history of radiotherapy and the use of granulocyte colony factor were the significant risk factors of severe neutropenia in the lung cancer patients.Conclusion：For the patients with radiotherapy history,it is better to choose chemotherapy drugs with lower toxicity,decrease drug dosage or preventively use granulocyte colony factor.The rational use of rh G-CSF can alleviate chemotherapy-induced severe neutropenia.
出处
《中国药师》
CAS
2016年第5期896-898,共3页
China Pharmacist
基金
陕西省自然科学基金项目(编号:2013JM4052)
关键词
化疗
粒细胞减少
肺癌
危险因素
Chemotherapy
Neutropenia
Lung cancer
Risk factors
