摘要
目的：观察生长抑素施他林（Ｓｔｉｌａｍｉｎ）治疗急性重症胰腺炎的疗效。方法：１９９４年１月至１９９８年３月共收治急性重症胰腺炎３６例，其中１９９４年１月至１９９６年９月收治的２０例，按病情常规治疗为对照组，１９９６年１０月至１９９８年３月收治的１６例，在常规治疗的基础上加用施他林持续静脉点滴５～７ｄ为治疗组，通过血淀粉酶下降程度，转手术治疗率、并发症、住院日等指标观察两组疗效差异。结果：治疗组入院后１０ｄ血淀粉酶１００％降至正常，对照组５０％降至正常（Ｐ＜００１）。治疗组无一例手术治疗，对照组９例（４５％）转手术治疗。治疗组出现并发症１４例次，对照组２０例次。住院时间治疗组２３９３±１１３７ｄ，对照组４２２８±２４５２ｄ（Ｐ＜００５）。结论：施他林能有效地抑制胰液、胰酶的分泌，在发病初期开始应用，能在一定程度上控制病情发展，减少手术治疗率及并发症的发生，缩短住院时间。
Objective:To obserce the curative effect of stilamin(somatostin serono)in the treatment of acute severe pancreatitis.Methods:36 cases collected from January,1994 to March,1998(of 36 cases20 ones from January,1994 to september,1996)are regarded as the control group while 16 cases from October,1996 to March,1998 as the testgroup.The control group were given a routine measure of treatment while the test group the mixed measures of the conventional treatment and stilamin through intravenously way(5 to 7 days).The difference between the control group and the test one are contrasted through the decrease of blood amylocast,operation rate,complications and the time ofhospitalization.Results:Blood amylocast in the test group totally decreased to a normal level in 10 days after hospitalization while only 50% of cases in the control group got down to the normal(P<0 01).No one had an operation in the test group but 9 cases(47%)in the control group got an operation.14 cases in the test group and 20 cases in the control group had complications separately,The time ofhospitalization is 23 93±11 37days in the test group while 42 28±24 52days in the control group(P<0 05),Conclusions:Stilamin can effectively inhibit the secretion of pancreas including the secretion of panceatic enzyme.It can also control the development of the disease,shorten the period of hospitaloation and deduce the operation rate and the occurrence of complications.
