摘要
小细胞肺癌(SCLC)是最常见的易伴发副瘤综合征的恶性肿瘤。SCLC相关性副瘤综合征包括内分泌副瘤综合征与神经系统副瘤综合征。通常由源于肿瘤细胞的异位激素分泌或神经抗原介导的免疫性组织破坏导致,并与患者的预后存在相关性。本文着重对小细胞肺癌中最常见的副瘤综合征如低钠血症、LambertEaton综合征及抗Hu抗体介导的副瘤综合征等的病理机制、临床特点、诊治进展及预后进行述评。深入探讨副瘤综合征的病理机制与SCLC临床特点和预后的内在联系,为SCLC的治疗提供新思路。
Small cell lung cancer （SCLC） is the most common malignancy associated with paraneoplastic syndromes. SCLC related paraneoplastic syndromes include endocrine paraneoplastic syndromes and neurological paraneoplastic syn- dromes, which are typically caused by ectopic hormone production or neural antigen - mediated immune tissue destruc- tion, and are associated with the prognosis of patients. This article discusses the most common ectopic hormone and neurologic paraneoplastic syndromes, such as hyponatrimia, Lambert - Eaton syndrome and anti - Hu antibody media- ted paraneoplastic syndromes, and emphasizes the pathologic mechanism, clinical features, management and outcomes. An intensive study of the relationship among pathologic mechanism, clinical features and outcomes will provide new treatment strategy for SCLC.
出处
《大连医科大学学报》
CAS
2016年第2期105-108,共4页
Journal of Dalian Medical University
基金
国家自然科学基金项目(81572881)
