摘要
目的探讨乌司他丁联合奥曲肽在急性胰腺炎患者中的临床治疗效果，为临床提供依据。方法选取2013年2月-2016年2月在我院住院治疗的急性胰腺炎患者60例，依据治疗措施分为对照组30例和观察组30例。对照组采用大柴胡汤加减治疗，观察组采用乌司他丁联合奥曲肽治疗,比较两组临床疗效。记录患者治疗后症状改善时间。结果观察组治疗有效率为93.3％，显著高于对照组的80．0％（P〈0．05）；观察组患者治疗后的腹痛缓解时间、首次排便时间、血淀粉酶恢复正常时间以及住院时间显著短于对照组（P〈0．05）；两组患者治疗前、后IL-10水平差异无统计学意义（P〉0．05）；两组患者治疗前TNF—α、IL-2、IL-6及IL-8水平差异无统计学意义（P〉0．05）；观察组治疗后的TNF-α、IL-2、IL-6及IL-8水平显著低于对照组（P〈0．05）。结论与大柴胡汤加减治疗效果比较，急性胰腺炎患者采用乌司他丁联合奥曲肽治疗能提高临床疗效，缩短症状改善时间，并发症发生率低，
Objective To discuss the clinical effects of ulinastatin combined with octreotide in patients with acute pancreatitis and to provide basis for clinical practice. Methods 60 patients with acute pancreatitis treated in our hospital from February 2013 to February 2016 were selected and divided based on therapeutic measures into control group and observation group, each with 30 cases. Patients in the control group were given Dachaihu decoction modified therapy, while patients in the observation group were given ulinastatin combined with octreotide. The clinical effects were compared between two groups and remission time of symptoms was recorded. Results The treatment efficiency was 93.3% in the observation group, which was significantly higher than that in the control group （80.0%, P〈0.05）. After treatment, the remission time of abdominal pain, time to first defecation, recovery time of hemodiastase, and hospital stay were significantly shorter in the observation group than in the control group（P〈0.05）. There was no significant difference in IL-10 level before and after treatment in two groups（P〉0.05）. There were also no significant differences in levels of TNF-α, IL-2, IL-6, and IL-8 between two groups before treatment, while after treatment, the levels of TNF-α, IL-2, IL-6, and IL-8 were significantly lower in the observation group than in the control group （P〈0.05）. Conclusion Compared with Dachaihu decoction modified therapy, ulinastatin combined with oetreotide has more significant clinical effects in patients with acute pancreatitis, shorter remission time of symptoms, and low incidence of complications, which is worthy to be promoted.
出处
《中国现代医生》
2016年第11期82-85,共4页
China Modern Doctor
关键词
乌司他丁
奥曲肽
急性胰腺炎
大柴胡汤
并发症
Uinastatin
Otreotide
Acute pancreatitis
Dachaihu decoction
Terapeutic effect
Complication
