摘要
目的探讨血小板计数、白细胞总数与登革热临床类型之间的相关性。方法在2014年广州市白云区确诊的登革热病例中随机抽取典型登革热病例308例、登革出血热或登革休克综合征病例79例。回顾性收集其人口学信息及临床资料,分别应用单因素和多因素Logistic回归进行分析。结果相对于血小板计数正常组,血小板计数中度减少组和重度减少组发生登革出血热/登革休克综合征的风险均更大,调整后OR值分别为5.02（95%CI：2.01~12.79）和13.45（95%CI：1.50~304.60）;而血小板轻度减少组与正常组差异无统计学意义,调整后OR值为1.23（95%CI：0.61~2.60）。相对于白细胞总数正常组,白细胞总数轻度减少组或重度减少组发生登革出血热/登革休克综合征的风险也更大,调整后OR值分别为4.39（95%CI：1.22~28.13）和7.20（95%CI：1.97~46.65）。结论登革热患者血小板计数和白细胞总数减少程度越大,出现登革出血热/登革休克综合征的风险越高。
Objective To explore the association between levels of thrombocyte or leukocyte and clinical types of dengue.Methods 387 dengue cases in Baiyun district, Guangzhou city in 2014 were selected and surveyed, including 308 classical dengue fever（DF） cases and 79 dengue hemorrhagic fever（DHF） or dengue shock syndrome（DSS） cases. Univariate analysis and multivariate analysis by logistic regression were used in this study. Results Multivariate logistic regression showed that patients with thrombocytopenia had higher risk of appearing to DHF or DSS, with ORs of 5.02（95% CI： 2.01 ~12.79） for those had medium thrombocytopenia and 13.45（95% CI： 1.50~304.60） for those had severe thrombocytopenia,while the mild thrombocytopenia group was not significantly different from the normal one, with OR=1.23（95%CI： 0.61~2.60）.The leukocytopenia group at a level of（2~4） ×109/ L or 2 ×109/L also had higher risk of DHF or DSS, with ORs of 4.39（95%CI： 1.22~28.13） and 7.20（95%CI： 1.97~46.65）, respectively. Conclusion The lower the thrombocyte or leukocyte level, the higher risk of DHF or DSS.
出处
《热带医学杂志》
CAS
2016年第4期523-526,共4页
Journal of Tropical Medicine
基金
国家自然科学基金(81373050)
广东省自然科学基金(S2013010013637)
广州市卫生局项目(20141A011057)
