摘要
特应性皮炎是一种不仅局限于皮肤的炎症性疾病。除皮肤损害外,患者常合并哮喘、过敏性鼻炎和食物过敏,其皮肤对细菌和病毒的易感性增加,一些免疫缺陷综合征常伴有特应性皮炎表现。近年还发现,特应性皮炎与注意缺陷多动障碍等行为异常密切相关,其机制尚不完全清楚。进一步阐明特应性皮炎与躯体或精神障碍合并症之间的潜在生物学机制,可能会增加临床医师对特应性皮炎发病机制的理解,并有助于研发靶向干预特应性皮炎的治疗或预防措施。
Atopic dermatitis is an inflammatory disease with negative impact often extend beyond the skin. It is well established that AD is associated with certain allergic comorbidities such as asthma,allergic rhinitis and food allergies. Patients with AD are also susceptible to developing cutaneous bacterial and viral infections. More recently,strong data have emerged highlighting an association between AD and the neurobehavioral disorder of attention deficit hyperactivity disorder. The mechanisms underlying these associations remain elusive. Understanding the biological mechanisms of the relationship between AD and other somatic and / or mental disorders may help to increase our understanding of the pathophysiology of AD and eventually lead to the development of targeted preventive or curative interventions.
出处
《中国医学文摘（皮肤科学）》
2016年第2期169-173,共5页
China Medical Abstracts(Dermatology)
关键词
特应性皮炎
合并症
哮喘
注意缺陷多动障碍
皮肤屏障
Atopic dermatitis
Comorbidity
Asthma
Attention deficit hyperactivity disorder
Skin barrier
