摘要
目的了解帕金森病(PD)患者的血清β-淀粉样蛋白1-42(Aβ1-42)水平,并探讨其与病情的关系。方法选取2014年5月—2015年5月到新疆医科大学第一附属医院神经内科就诊的PD患者108例为病例组;另选取同时期在本院体检中心进行体检的健康成年人108例为对照组。收集两组的一般资料,并检测其血清Aβ1-42水平。以病程、统一帕金森病评定量表(UPDRS)评分及Hoehn-Yahr(H-Y)分级判断PD患者的病情严重程度,分析血清Aβ1-42水平与病情的相关关系。结果两组血清Aβ1-42水平比较,差异有统计学意义(P<0.05)。以性别分层,两组男性受试者的血清Aβ1-42水平比较,差异有统计学意义(P<0.05);而两组女性受试者的血清Aβ1-42水平比较,差异无统计学意义(P>0.05)。以年龄分层,两组≤60岁受试者的血清Aβ1-42水平比较,差异无统计学意义(P>0.05);两组>60岁受试者的血清Aβ1-42水平比较,差异有统计学意义(P<0.05)。以民族分层,两组汉族受试者的血清Aβ1-42水平比较,差异有统计学意义(P<0.05);两组维吾尔族受试者的血清Aβ1-42水平比较,差异无统计学意义(P>0.05)。早期和中晚期患者的血清Aβ1-42水平比较,差异无统计学意义(P>0.05)。Spearman秩相关分析显示,血清Aβ1-42水平与PD患者病程无相关性(r_s=0.06,P>0.05);与UPDRS第Ⅰ部分评分(r_s=-0.11,P>0.05)、第Ⅱ部分评分(r_s=-0.09,P>0.05)、第Ⅲ部分评分(r_s=0.10,P>0.05)无相关性;与H-Y分级呈负相关(r_s=-0.25,P<0.05)。结论 PD患者血清Aβ1-42水平较低,血清Aβ1-42水平可能为PD临床诊断中的新型生物学指标,但尚不能作为病情严重程度的判断指标。
Objective To investigate the level of serum β-amyloid protein 1-42（ Aβ1-42） and its relationship with the disease status of patients with Parkinson disease（ PD）. Methods A total of 108 PD patients who received treatment in the Department of Neurology of the First Affiliated Hospital of Xinjiang Medical University from May 2014 to May 2015 were enrolled as case group. We also enrolled 108 healthy adults who received physical examination in the physical examination center of the hospital during the same period as control group. General data of the two groups were collected,and serum Aβ1-42 level was detected. The disease severity of these PD patients were determined by length of disease,Unified PD Rating Scale（ UPDRS）score and Hoehn-Yahr（ H-Y） grading, and the correlation between serum Aβ1-42 level and disease severity was investigated. Results The two groups were significantly different in serum Aβ1-42 level（ P 〈0. 05）. With gender stratification,the two groups were significantly different in the serum Aβ1-42 level of male subjects（ P 〈0. 05）,and the two groups were significantly different in the serum Aβ1-42 level of female subjects（ P 〉0. 05）. With age stratification,the two groups were not significantly different in the serum Aβ1-42 level of patients aged ≤ 60（ P 〉0. 05）, and the two groups were significantly different in the serum Aβ1-42 level of patients aged〉 60（ P 〈0. 05）. With nationality stratification,the two groups were significantly different in the serum Aβ1-42 level of Han subjects（ P 〈0. 05）,and the two groups were not significantly different in the serum Aβ1-42 level of Uygur subjects（ P 〉0. 05）. Patients at early stage and patients at middle and late stage were not significantly different in serum Aβ1-42 level（ P 〉0. 05）. Spearman correlation analysis showed that serum Aβ1-42 level had no correlation with the length of disease of PD patients（ r_s= 0. 06,P 〉0. 05）,had no correlation with part Ⅰ score（ r_s=-0.
出处
《中国全科医学》
CAS
CSCD
北大核心
2016年第10期1165-1169,共5页
Chinese General Practice
基金
新疆维吾尔自治区高技术研究发展项目(201417101)
关键词
帕金森病
淀粉样蛋白
病情
Parkinson disease Amyloid Disease severity
