摘要
目的研究眼眶肿瘤患者放疗后脑白质微观结构的动态改变与其神经认知功能的相关性。方法选取在2013年12月至2014年12月之间,在我院应用γ刀放射外科治疗治疗眼眶肿瘤的患者100例。将患者随机分为4组,A组为放疗前组(n=25),B组为放疗后1个月组(n=25),C组为放疗后6个月组(n=25),D组为放疗后12个月组(n=25)。各组分别行γ刀放射治疗措施,所有受试者均行神经心理学测试和磁共振扩散张量成像(DTI)检查。结果比较4组MMSE评分发现,放射治疗前的患者MMSE评分最高,放射治疗后1个月时MMSE评分最低,到放射治疗后12个月基本恢复正常(P<0.05)。比较4组各向异性比值(FA)发现,放射治疗前的患者各向异性比值(FA)最高,放射治疗后1个月时各向异性比值(FA)最低,到放射治疗后12个月基本恢复正常(P<0.05)。各组患者MMSE评分与各向异性比值的关系:两者间呈现出高度的一致性,呈正相关关系。结论眼眶肿瘤患者放疗后脑白质微观结构的损伤与其神经认知功能的障碍,而且两者具有正向的相关关系。
Objective To investigate the correlation between changes in white matter microstructure and neurocognitive function after gamma knife radiotherapy in patients with orbital tumor. Methods Between December 2013 and December 2014,totally 100 patients with orbital tumor who were treated with gamma knife radiotherapy in our hospital were enrolled. Patients were randomly divided into four groups（ each n = 25）. Group A received neurocognitive function tests before radiotherapy. Group B at 1 months after radiotherapy. Group C at 6 months,and group D at 12 months. Neurocognitive tests included neuropsychological tests and magnetic resonance diffusion tensor imaging（ DTI）. Results MMSE score was highest before radiotherapy（ group A） and lowest at 1 month after radiotherapy（ group B）. By 12 months,MMSE returned to pre-treatment level（ P〈0. 05）. The anisotropy ratio（ FA） was also highest before radiotherapy and lowest at 1month,and returned to baseline at 12 months after radiotherapy（ P〈0. 05）. The MMSE score is highly correlated with anisotropy ratio. Conclusions Orbital tumor radiotherapy could result in cerebral white matter microstructural damage,which is strongly correlated with neurocognitive dysfunction.
出处
《临床眼科杂志》
2016年第2期149-152,共4页
Journal of Clinical Ophthalmology
关键词
眼眶肿瘤
脑白质
微观结构
动态改变
认知功能
Ocular tumor
Brain white matter
Microstructure
Dynamic change
Cognitive function
