摘要
帕金森病轻度认知功能障碍(PD-MCI)是指由帕金森病(PD)所致的对日常生活功能影响很小且没有进展为痴呆的一组认知功能障碍综合征,对预测帕金森病痴呆(PDD)的风险有潜在价值。随着国际运动障碍协会(MDS)对PD-MCI诊断标准的提出,一系列研究应用此标准在PD-MCI发生、发展等方面提供新观点,并对此诊断标准的合理性进行初步评价。本文就PD-MCI的流行病学及危险因素、临床亚型特点、诊断、转归、治疗做一综述,提示PD-MCI发病率较高,有多种临床亚型,但目前尚缺乏有效的治疗手段,需要更深入的研究加以探索。
Parkinson disease with mild cognitive impairment（PD-MCI）is a cognitive dysfunction syndrome,which is caused by Parkinson disease（PD）,and PD-MCI has potential value in the prediction of Parkinson disease dementia（PDD）. PD-MCI produces little effect on the ability of daily life and has not developed dementia yet. After the diagnostic criteria of PD-MCI was put forward by international Movement Disorders Society（MDS）,new ideas have been put forward by a series of studies in the aspects of occurrence and development of PD-MCI by applying the criteria,and the rationality of the diagnostic criteria has been evaluated preliminarily. In this paper,epidemiology,risk factors,the characteristic of clinical subtypes,diagnosis, prognosis and therapy of PD-MCI were summarized,which suggested that the morbidity of PD-MCI with various clinical subtypes is high,while valid treatment means curing PD-MCI are still lacking at present and deeper research needs to be explored.
出处
《中国全科医学》
CAS
CSCD
北大核心
2016年第12期1371-1374,共4页
Chinese General Practice
关键词
帕金森病
轻度认知功能障碍
痴呆
危险因素
预后
治疗
Parkinson disease
Mild cognitive impairment
Dementia
Risk factors
Prognosis
Therapy
