摘要
目的:分析李济仁教授治疗活动期类风湿关节炎的用药规律,为中医药治疗活动期类风湿关节炎提供参考。方法:收集2013年1月—2014年12月李济仁教授治疗活动期类风湿关节炎的处方,基于中医传承辅助系统构建数据库,进而应用关联规则等数据挖掘方法,得到药物频次、药物组合、关联规则和核心组合等,分析李济仁教授治疗类风湿关节炎的用药规律。结果:运用中医传承辅助系统对筛选出的84首处方进行分析,得到治疗活动期类风湿关节炎的高频词药物为青风藤、苦参、萆薢等清热利湿药物,黄芪、当归、鸡血藤、大血藤、乳香、没药等补气活血通络药物;全蝎、蜈蚣等搜风通络止痛药物;制川乌、制草乌、桂枝等温经通络止痛药物,同时挖掘出35个核心组合和9首新处方。结论:李济仁教授治疗活动期类风湿关节炎经验丰富。他主张风寒湿热之邪在活动期类风湿关节炎的病因中具有重要意义,在辨证时,重视"寒、热",以寒热平调、标本兼顾、顾护脾胃为治疗原则,以清络饮为主方,以风寒湿热的偏性、复杂转化为依据,寒热配伍用药,随症加减,使寒药不伤阳气、热药不伤阴精。
Objective： To analyze the medication rules given by professor LI Ji-ren for treatment of active rheumatoid arthritis（ RA）,and provide reference for traditional Chinese medicine（ TCM） treatment in active RA. Method： Prescriptions used for active RA in January 2013—December 2014 given by professor LI Jiren were collected. Then the data was entered into TCM inheritance support system to build a database,and drug frequency,drug combination,association rules and core combinations were obtained by using data mining methods such as association rule,to analyze professor LI Ji-ren’s medication rules for the treatment of RA. Result： By analyzing 84 screened prescriptions based on TCM inheritance support system,high frequency herbs for the activity RA included the clearing heat and promoting diuresis herbs such as Scolopendra,Sophorae Flavescentis Radix,Dioscoreae Hypoglaucae Rhizoma; tonifying Qi and invigorating blood circulation herbs such as Astragall Radix,Angellcae Sinensis Radix,Spatholobi Caulis,Sargentodoxae Caulis,Olibanum,Myrrha; expelling wind,dredging collateral and pain reliving herbs such as Scorpio,Scolopendra; warming and activating meridian and pain relieving herbs such as Aconitti Radix Cocta, Aocniti Kusnezoffii Radix Cocta, and Cinnamomi Ramulus.Meanwhile,35 core combinations and 9 new prescriptions were dig out. Conclusion： Professor LI Ji-ren is experienced in treatment of active RA. He believes that the pathogenic wind-cold damp-heat is of great significance in the activity of rheumatoid arthritis etiology. In the syndrome differentiation, the ‘cold, hot ’ should be emphasized. Mildly regulating cold and heat,relieving both primary and secondary symptoms and protecting spleen and stomach shall act as the treatment principles,Qingluoyin as the main composition,with compatibility of cold and heat drugs based on the bias and complex transformation of wind-cold damp-heat. The herbs can be added or subtracted according to the symptoms,so that the cold herbs would not hurt Yangqi an
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第8期221-225,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局重点学科中医痹病学建设项目(国中医药人教发[2012]32号)
安徽省科技厅科技攻关项目(11010402173)
安徽省卫生计生委中医药科研项目(2014zy27)
皖南医学院重点科研项目(WK2015ZF06)
关键词
类风湿关节炎
数据挖掘
关联规则
用药规律
rheumatoid arthritis
data mining
association rules
medication rules
