摘要
恶性肿瘤具有高发病率和高死亡率的特点,严重威胁人类的健康。尽管人们不断探索新的肿瘤治疗方法,但现阶段恶性肿瘤的预后仍然较差。因此深入研究肿瘤的发病机制,鉴定致癌基因,无论对于分子标志物的开发还是治疗靶点的确定都具有重要意义。近年的研究表明,恶性肿瘤常发生钙离子激活氯离子通道蛋白1（anoctamin 1,ANO1）的扩增和过表达,并且其功能改变与肿瘤的发生发展密切相关,因此本文将综述ANO1在恶性肿瘤细胞增殖、
Anoctamin 1（ ANO1） is a calcium-activated chloride channel and is amplified and over-expressed in gastrointestinal stromal tumor,breast cancer,bladder cancer,head and neck squamous cell cancer,esophageal squamous cell cancer,prostate cancer and pancreatic cancer. The amplification and over-expression of ANO1 are associated with lymph node metastasis and poor prognosis. ANO1 promotes tumor formation and metastasis,and the drugs that inhibit the activity or expression of ANO1 show antitumor effects. Therefore,ANO1 may promote the tumorigenesis,and may be a molecular biomarker and a new target for cancer therapy.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2016年第4期759-761,768,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81460425)
云南省应用基础研究计划青年项目(No.2013FD012)
