摘要
目的:探讨睑板腺分泌物及泪液中前列腺素E_2(prostaglandin E_2,PGE_2)含量与睑板腺功能障碍的相关性。方法:将72例120眼睑板腺功能障碍患者分为轻中度组36例60眼和重度组36例60眼,采用酶联免疫吸附试验检测睑板腺分泌物和泪液中PGE_2的含量。正常人30例60眼设为对照组,只检测泪液中PGE_2含量。结果:泪液中PGE_2含量在三组间差异有显著统计学意义(F=100.26,P<0.01),重度组泪液PGE_2含量高于轻中度组(t=5.789,P<0.01)和正常组(t=7.468,P<0.01),轻中度组泪液PGE_2含量与正常组差异无统计学意义(t=0.923,P>0.05);睑板腺分泌物PGE_2含量在两组间差异有统计学意义,重度组高于轻中度组(F=151.76,P<0.01);重度组泪液与睑板腺分泌物中PGE_2含量呈正相关(r=0.71,P<0.01);轻中度组泪液与睑板腺分泌物PGE_2含量呈正相关(r=0.30,P<0.05)。结论:睑板腺分泌物和泪液PGE_2含量对判断睑板腺功能障碍的严重程度和指导临床合理用药具有重要作用。
AIM ： To investigate the correlation between the severity of M eibomian gland dysfunction（ M GD） and the prostaglandin E2（ PGE2） content in Meibomian gland secretions and tear. METHODS： Seventy- two patients with MGD were divided into mild to moderate group（ 36 patients with 60eyes） and severe group（ 36 patients with 60 eyes）. The content of PGE2 in M eibomian gland secretions and tear were tested by ELISA. Thirty healthy adults（ 60 eyes）were chosen as the control group which were only tested for PGE2 in tear.RESULTS： The differences of the content of PGE2 in tear in the three groups were significant（ F = 100. 26,P〈0. 01）,and that in the severe group was higher than that in the mild to moderate group（ t = 5. 789,P〈0. 01） and the control group（ t = 7. 468,P〈0. 01）. There was no significant difference of the content of PGE2 in tear between the mild to moderate group and control group（ t =0. 923,P〈0. 05）. The differences of the content of PGE2 in M eibomian gland secretions in three groups were significant and that in the severe group was much higher than that in the mild to moderate group（ F = 151. 76,P〈0. 01）. The content of PGE2 in M eibomian gland secretions were positive correlated to the content of PGE2 in tears in severe group（ r = 0. 71,P〈0. 01）; the content of PGE2 in M eibomian gland secretions was positive correlated to the content of PGE2 in tears in mild to moderate group（ r = 0.30,P〈0. 05）. CONCLUSION： The level of PGE2 in M eibomian gland secretions and tears plays an important role in judging the severity of M GD and guiding clinical rational drug use.
出处
《国际眼科杂志》
CAS
2016年第5期990-992,共3页
International Eye Science
基金
广东省临床用药研究基金(No.2015RL07)~~
关键词
睑板腺功能障碍
睑板腺分泌物
前列腺素E2
相关性分析
Meibomian gland dysfunction
Meibomian gland secretions
prostaglandin E2
correlation analysis
