摘要
目的观察卡介菌多糖核酸联合5-氨基酮戊酸光动力(ALA-PDT)治疗尖锐湿疣临床效果及基因型检测。方法采用单盲对照试验将76例尖锐湿疣患者随机分成试验组(41例)和对照组(35例),试验组采用卡介菌多糖核酸联合ALA-PDT治疗,对照组采用ALA-PDT治疗。全部患者每次治疗前均先用CO2激光祛除肉眼可见疣体。首次治疗时取部分疣体行人乳头瘤病毒(HPV)基因型检测。ALA-PDT治疗每周1次,共4次,卡介菌多糖核酸隔日1次肌注,持续8周。治疗结束后随访6个月,观察复发率。结果试验组和对照组治愈率分别为95.1%、74.3%(P<0.05),复发率分别为2.4%、20.0%(P<0.05)。基因型检测结果:共检出71例15种,前三位依次为:HPV-6、HPV-16和HPV-11,未发现HPV 39、43、44、51、53和CP8304型,其中高危型47例、低危型26例、"高+低危型"混合交叉感染2例。单重感染60例,多重感染11例。结论卡介菌多糖核酸联合ALA-PDT治疗尖锐湿疣临床效果明显,复发率低。基因型检测结果说明高危型感染率明显偏高,多重感染较少。
Objective To observe the efficacy of BCG-PSN combined with ALA-PDT in treatment of condyloma acuminatum and test the genotyping of HPV. Methods All patients with condyloma acuminatum were randomly divided into test group（ n = 41）and control group（ n = 35）. The test group was treated with BCG-PSN combined with ALA-PDT,while the control group was treated with ALA-PDT only. The visible warts were burn up by CO2 laser before each treatment in all patients. Prior to the first session,HPV genotype of wart tissue was tested. The ALA-PDT was treated once a week and last for 4 weeks and the BCG-PSN was injected every two days and last for 8 weeks. Follow-up was scheduled on month 6 after the last treatment for the observation of recurrence rate. Results The cure rate of two groups was 95. 1% and 74. 3%（ P〈0. 05） and the recurrence rate was 2. 4% and 20. 0%（ P〈0. 05）.All 71 cases had 15 kinds of HPV genotype,except HPV-39,43,44,51,53 and CP8304. The top three were HPV-6,HPV-16 and HPV-11 respectively. The high-risk,the low-risk and the high / lower-risk HPV genotypes were 47 cases,26 cases and 2 cases respectively. The single and multiple infection were 60 cases and 11 cases respectively. Conclusion The efficacy of the test group is superior to the control group. High-risk HPV genotypes predominate in all patients and multiple infections is few.
出处
《东南国防医药》
2016年第2期177-179,共3页
Military Medical Journal of Southeast China
关键词
尖锐湿疣
卡介菌多糖核酸
光动力治疗
condyloma acuminatum
Bacillus Calmette-Guerin-polysaccharile nucleic acid（BCG-PSN）
photodynamic therapy
