摘要
目的探讨高分辨磁共振血管壁成像(high-resolusion magnetic resonance vessel wall imaging,HR-VWI)评估颅内动脉瘤的可行性。方法根据动脉瘤是否破裂,将接受HR-VWI检查的颅内动脉瘤分为破裂组(n=12)和未破裂组(n=88),对比两组动脉瘤的部位、大小、瘤颈宽度、高/颈比(aspect ratio,AR)、子囊和瘤壁强化等级。以动脉瘤是否破裂为因变量,以上各因素为自变量进行单因素和多因素Logistic回归分析。未破裂动脉瘤中,对症状性亚组(n=8)和无症状亚组(n=80)进行对比分析。结果破裂组的动脉瘤大小(t=2.187,P=0.031)、AR(t=3.164,P=0.002)、子囊比例(P=0.012)和瘤壁强化分级(P<0.001)大于未破裂组。多因素Logistic回归提示瘤壁强化等级是破裂动脉瘤的独立危险因素(P=0.002)。未破裂动脉瘤中,症状性亚组瘤壁强化分级(P<0.001)和AR(t=3.939,P<0.001)大于无症状亚组。结论破裂动脉瘤中HR-VWI瘤壁强化分级高于未破裂动脉瘤,症状性未破裂动脉瘤存在瘤壁强化现象。有必要获得瘤壁的组织学标本,与HR-VWI结果对照分析,进一步研究瘤壁强化的机制和意义。
Objective The present study was to investigate the feasibility of use of high resolution magnetic resonance vessel wall imaging（HR-VWI）in evaluation of intracranial aneurysms.MethodsWe prospectively collected data from patients who had intracranial aneurysms and received HR-VWI scan before surgical treatment or conservative treatment. Aneurysms were divided into ruptured group（n=12）and unruptured group（n=88）. Aneurysm site, size,neck, aspect ratio（AR）, daughter sac and aneurysmal wall enhancement scale were analyzed in both groups. Univariate and multivariate Logistic regression were performed to evaluate the risk factors of aneurysm rupture. Subgroup analysis was also performed to study symptomatic and asymptomatic unruptured aneurysms.ResultsAneurysm size（t=2.187,P=0.031）,AR（t=3.164,P=0.002）,incidence of daughter sac（P=0.012）and aneurysmal wall enhancement scale（P0.001）were higher in ruptured aneurysm group. Multivariate Logistic regression showed that aneurysmal wall enhancement scale was the only independent risk factor of ruptured aneurysms（P=0.002）. Subgroup analysis showed aneurysm wall enhancement scale（P0.001） and AR（t=3.939,P0.001） were higher in symptomatic unruptured aneurysms.ConclusionAneurysm wall enhancement on HR-VWI is more frequently seen in ruptured aneurysms and symptomatic unruptured aneurysms. Histological study is needed for better understanding of the mechanism of aneurysm wall enhancement.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2016年第3期175-179,共5页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金(编号:81171102)
关键词
高分辨磁共振
血管壁成像
颅内动脉瘤
High-resolusion magnetic resonance
Vessel wall imaging
Intracranial aneurysm
