摘要
目的研究张家界市土家族与汉族女性中5,10-亚甲基四氢叶酸还原酶(MTHFR)及甲硫氨酸合成酶还原酶(MTRR)基因的单核苷酸多态性分布特征。方法通过横断面调查研究方法,于2015年5-11月选取湖南省张家界市1 065名土家族和333名汉族女性为研究对象,检测其叶酸代谢过程中编码关键酶的相关基因MTHFR C677T、A1298C和MTRR A66G基因位点多态性,统计分析该地区基因多态性的分布特征,并与已报到的贵州思南地区土家族妇女数据进行统计学比较。结果该地区的土家族MTHFR C677T、A1298C和MTRR A66G基因型频率与等位基因频率与汉族女性及贵州思南地区的土家族女性比较,差异均无统计学意义(P均>0.05)。结论张家界市土家族与汉族女性以及与贵州思南地区土家族女性MTHFR C677T、A1298C和MTRR A66G基因多态性分布无显著差异。
Objective To investigate the distribution features of methylenetetrahydrofolate reductase（ MTHFR） and methionine synthase（ MTRR） single nucleotide polymorphisms among Tujia nationality women and Han women in Zhangjiajie city. Methods A cross-sectional study was conducted among 1 065 Tujia nationality women and 333 Han women from Zhangjiajie city from May to November in 2015,polymorphisms of MTHFR C677T,A1298C and MTRR A66G were detected,the distribution features of gene polymorphisms were analyzed statistically,then the results were compared with reported data of Tujia nationality women from Si＇nan county of Guizhou province.Results There was no statistically significant difference in the frequencies of MTHFR C677 T,A1298C and MTRR A66G genotypes and alleles among Tujia nationality women in Zhangjiajie city,Han women in Zhangjiajie city and Tujia nationality women in Si＇nan county（ P〈0.05）. Conclusion The distributions of MTHFR C677T,A1298C and MTRR A66G polymorphisms among Tujia nationality women is not different from Han women in Zhangjiajie city and Tujia nationality women in Si＇nan county.
出处
《中国妇幼保健》
CAS
2016年第9期1898-1901,共4页
Maternal and Child Health Care of China
基金
中国疾病预防控制中心妇幼保健中心妇幼保健分子遗传医学研究专项计划(FY-ZX-ZD-0227)
关键词
张家界市
土家族女性
单核苷酸多态性
MTHFR
MTRR
Zhangjiajie city
Tujia nationality woman
Single nucleotide polymorphism
Methylenetetrahydrofolate reductase
Methionine synthase reductase
