摘要
目的研究c-met和Ezrin在大肠癌组织中表达及其临床病例和预后关系。方法应用免疫组织化学方法检测35例大肠癌组织及20例癌旁组织中c-met和Ezrin表达水平,分析c-met和Ezrin表达与各临床病理关系。结果大肠癌组织中c-met和Ezrin表达水平明显高于癌旁组织(P<0.05)c-met和Ezrin表达水平与肿瘤的的侵犯,分化程度,淋巴结转移有关(P<0.05),与性别,年龄,肿瘤部位无关(P>0.05),c-met和Ezrin在大肠癌组织中呈正相关(rs=0.614,p=0.000)。结论 c-met和Ezrin与大肠癌的发生,侵袭,转移密切相关,两者在大肠癌的发生,转移有可能有协同作用,联合检测c-met和Ezrin有助于判断大肠癌的侵犯,转移和预后。
Objective To investigate the expression of c- met and Ezrin in colorectal cancer tissues,and explore the relationship between its clinical pathology significence with prognosis. Methods The immunohistochemical method was used to detect the expression of c- met and Ezrin in 35 cases of colorectal cancer and 20 cases of adjacent tissue,and then to analyze the relationship between the expression of c- met and Ezrin with patients clinical pathology. Results The expression of c- met and Ezrin in colorectal cancer tissue level is significantly higher than that in the tissue adjacent to carcinoma（ P〈0. 05）. The expression of c- met and Ezrin was positively correlated with tumor invasion,the degree of differentiation,and lymph node metastasis（ P〈0. 05）,and has no relastionship with the gender,age,and tumor location not（ P〉0. 05）. The expression of c- met and Ezrin in colorectal cancer tissues were positively correlated（ rs = 0. 614,p = 0. 614）. Conclusion The expression of c- met and Ezrin is closely related to the incidence,invasion and matastasis of colorectal cancer. Combined detection of c- met and Ezrin is helpful for determine colorectal cancer invasion,metastasis and prognosis.
出处
《牡丹江医学院学报》
2016年第2期9-12,共4页
Journal of Mudanjiang Medical University
