摘要
目的比较固定剂量法和滴定法给予普瑞巴林治疗中枢性卒中后疼痛的疗效。方法采取连续入组方式筛选入组厦门大学附属第一医院中枢性卒中后疼痛的患者,随机分为固定剂量法组和滴定法组。固定剂量法组给予普瑞巴林300 mg/d,连续服用8周;滴定法组给予普瑞巴林150 mg/d×2周,300 mg/d×2周,450 mg/d×4周。以数字评价量表（NRS）作为主要终点指标,以药物不良反应、医院焦虑抑郁量表（HADS）评分和睡眠自测量表（AIS）评分作为次要终点指标。结果 2013年7月-2014年12月在本院神经科和疼痛科筛选入组共计132例患者,随机分给固定剂量法组65例,滴定法组67例。两组因药物不良反应或难以坚持服药等原因分别退出2例、7例患者。固定剂量法组和滴定法组最终纳入统计的例数分别是63例和60例,两组间性别、年龄、病史、用药史等基础资料的比较差异均无统计学意义。与治疗前比较,固定剂量法组和滴定法组治疗后NRS评分、HADS-A评分、HADS-D评分及AIS评分均显著降低（均P〈0.05）。两组间治疗后NRS评分、HADS-A评分、HADS-D评分及AIS评分的比较,差异无统计学意义。结论固定剂量法和滴定法给予普瑞巴林治疗CPSP患者都是安全有效的,而固定剂量法的患者依从性似乎更高。
Objective To compare the effectiveness of Pregabalin given by fixed dose method and flexible dose method on treating central post-stroke pain. Methods Patients with central post-stroke pain were consecutively enrolled and randomized into fixed group and flexible group. The patients in fixed group were given pregabalin 300 mg per day for 8 weeks. The patients in flexible group were given pregabalin as follows： 150 mg per day for 2 weeks,300 mg per day for 2 weeks and 450 mg per day for 4 weeks. The primary outcome was numerical rating scale（ NRS）.The secondary outcomes included adverse effects,hospital anxiety and depression scales（ HADS） and Athens insomnia scale（ AIS）. Results A total of 132 participants were enrolled with 65 in fixed group and 67 in flexible group from Jul 2009 to Dec 2014. Two patients in fixed group gave up the treatment while 7 patients gave up in flexible group though no significant difference was observed. Finally,63 patients in fixed group and 60 patients in flexible group were included into analysis. There was no significant difference on gender,age,medical history between two groups. Compared with baseline, the NRS、HADS-A、HADS-D and AIS score were significantly decreased（ all P〈0. 05）. However,there was no significant difference of these scores between the two groups.Conclusion Two regimens of pregabalin showed the similar efficiency and safety to treat CPSP,however,fixed dose seemed to be more acceptable.
出处
《临床神经病学杂志》
CAS
北大核心
2016年第2期140-142,共3页
Journal of Clinical Neurology
关键词
普瑞巴林
中枢性卒中后疼痛
固定剂量法
滴定法
数字评价量表
Pregabalin
central post-stroke pain
fixed dose method
flexible dose method
numerical rating scale
