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A型急性主动脉夹层围手术期高血糖的危险因素 被引量:10

Risk factors for perioperative hyperglycemia in Stanford type A acute aortic dissection
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摘要 目的回顾性分析StanfordA型急性主动脉夹层围手术期高血糖的独立危险因素和并发症,探讨其血糖管理策略。方法连续收集2010年1月至2015年1月郑州大学人民医院大血管外科StanfordA型急性主动脉夹层患者195例,男130例,女65例。记录围手术期患者资料和血糖峰值,根据围手术期血糖峰值是否〉13.32mmol/L分为两组。将单因素分析差异具有统计学意义的变量进行lo—gistic多因素回归分析。记录围手术期并发症发生情况。结果多因素回归分析显示术前严重应激反应(白细胞:OR:2.343,95%CI:1.198~3.564,P=0.021;CRP:OR=2.459,95%CI:1.265~3.766,P=0.016)、体质量指数(OR=4.112,95%CI:1.346~6.121,P=0.009)、糖尿病(OR=4.766,95%CI:1.589~6.887,P=0.002)、深低温停循环时间(OR=1.989,95%CI:0.983~2.451,P=0.032)是StanfordA型急性主动脉夹层围手术期高血糖的独立危险因素。血糖≥13.32mmolfL组术后肺部感染[31(25.8%)对10(13.3%),P=0.037]、急性肺损伤[43(35.8%)对15(22.7%),P=0.019]和气管切开[13(10.8%)对2(2.7%),P=0.037]发生率显著增多,急性肾损伤发生率[32(26.7%)对10(13.3%),P=0.028]和CRRT使用率[26(21.7%)对7(9.3%),P=0.025]明显增多,机械通气时间[(3.8±1.3)天对(2.1±0.7)天,P〈0.001]、ICU停留时间[(7.1±3.5)天对(5.6±1.9)天,P〈0.001)和住院时间[(29±7)天对(23±3)天,P〈0.001]明显延长,短暂性神经功能障碍发生率[87(72.5%)对38(50.7%),P=0.002]和院内病死率[22(18.3%)对6(8.0%),P=0.045]明显增加。结论术前严重应激反应(白细胞和C反应蛋白)、体质量指数、糖尿病、深低温停循环时间是StanfordA型急性主动脉夹层围手术期高血糖的独立� Objective To analyze the independent risk factors and complications for perioperative hyperglycemia in Stanford type A acute aortic dissection undergoing emergency operation and investigate the management strategy of perioperative blood glucose. Methods Between January 2010 and January 2015 from the department of great vessel surgery of Zhengzhou Uni- versity People' s Hospital, 195 cases of patients with Stanford type A acute aortic dissection undergoing emergency operation were collected consecutively, 130 male and 65 female. The related data and perioperative peak blood glucose were recorded. According to the perioperative peak blood glucose, patients were divided into 2 groups: 〉 13.32 mmol/L group and 〈 13.32 mmol/L group. Univariate and logistic regression analysis were used to identify the independent risk factors. The perioperative complica- tions 1 were also recorded. Results Preoperative severe stress reaction(WBC: OR =2. 343, 95%CI: 1. 198 -3.564,P = 0.021 ;CRP: OR =2.459, 95%C1:1.265 -3.766, P=0.016) ,body mass index(OR =4. 112, 95%C1:1.346 -6. 121, P = 0. 009), diabetes mellitus ( OR = 4. 766, 95% CI: 1. 589 - 6. 887, P = 0. 002 ), circulatory arrest time ( OR = 1. 989, 95 % CI: 0.983 - 2.451, P = 0. 032) were the independent risk factors for perioperative hyperglycemia. The incidence rate of postoperative lunginfection[31(25.8%)vs. 10(13.3%), P=0.037]andacutelunginjury[43(35.8%)vs. 15(22.7%), P=0.019], as well as traeheotomy [ 13 ( 10.8 % ) vs. 2 (2.7 % ), P = 0. 037 ] in≥ 13.32 mmol/L group were significantly increased. Acute kid- ney injury[32(26.7% )vs. 10( 13.3% ), P =0. 0281 and CRRT usage[ 26(21.7% )vs. 7(9.3% ), P =0. 025 ] in≥13.32mmol/L group were significantly increased. The duration of mechanical ventilation [ (3.8 ± 1.3) days vs. (2.1 ±0.7) days, P 〈 0.001 ] and ICU stay time[ (7.1 ± 3.5 )days vs(5.6 ± 1.9 )days, P 〈 0. 001 ] and hospitalization time[ (29 ±7 )days vs. (23 ± 3
出处 《中华胸心血管外科杂志》 CSCD 2016年第4期230-233,共4页 Chinese Journal of Thoracic and Cardiovascular Surgery
基金 河南省重点科技攻关计划项目(132102310080)
关键词 STANFORD A型急性主动脉夹层 深低温停循环 围手术期处理 高血糖 Aortic dissection Deep hypothermic circulatory arrest Perioperative careHyperglycemia
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