摘要
目的研究血清CA199、CA72-4水平与贲门腺癌临床病理特征的关系,探讨血清肿瘤标志物对贲门腺癌病理特征的预测作用。方法回顾性收集173例贲门腺癌病例,对比血清CA199、CA72-4阳性和阴性病例的临床病理特征分布差异,分析两种肿瘤标志物联检阳性对贲门腺癌病理特征的预测作用。结果贲门腺癌患者治疗前血清CA199和CA72-4水平与性别、年龄无关(P>0.05),而与浸润程度和淋巴结转移呈正相关(P<0.05),且血清CA72-4水平还与分化程度相关(P<0.05),分化程度越低阳性率越高。两种肿瘤标志物联检阳性率与分化程度、浸润程度和淋巴结转移均呈正相关(P<0.05),大体类型为溃疡型患者联检阳性率较其他类型均高(P<0.05),联合检测对各种病理特征预测的敏感性均显著提高。结论血清CA199和CA72-4水平与贲门腺癌病理特征均相关,对预测贲门腺癌的病理特征有重要作用,联合检测能够提高预测的敏感度,联检阳性患者可能出现肿瘤分化程度较低,浸润较深及淋巴结转移,提示预后不良。
Objective To study the relationship between CA199,CA72- 4 levels in serum and the clinicopathological features of gastric cardia adenocarcinoma（ GCA）,and investigate the predictive roles of serum tumor markers on the pathological features of GCA. Methods 173 cases of gastric cardia adenocarcinoma were retrospectively collected. The distribution differences of clinicalopathological features among the cases with positive or negative CA199,CA72- 4 in serum were compared. The predictive effects of the two positive tumor markers on the pathological characteristics of GCA were analyzed. Results The CA199 and CA72- 4 levels in serum had no correlation with both gender and age before treatment in cardia adenocarcinoma patients（ P〈0. 05）,but had a positive relationship with infiltration and lymph node metastasis（ P〈0. 05）,and the CA72- 4levels also related with the degree of differentiation（ P〈0. 05）. The lower the degree of differentiation was,the higher the positive rate was. Furthermore,the positive rates of two tumor markers were positive correlated with the degree of differentiation,depth of invasion and lymph node metastasis（ P〈0. 05）. The positive rate of patient with ulcerative type were higher than other types（ P〈0. 05）. The prediction sensitivity of joint detection among various pathological features were significantly improved.Conclusion The CA199 and CA72- 4 levels in serum were associated with the pathological characteristics of gastric cardia adenocarcinoma. Both of them played an important role in predicting the pathological features of GCA. Combined detection could improve the sensitivity of prediction. The patients with positive results of joint detection probably appear the lower tumor differentiation,the deeper invasion and lymph node metastasis with poor prognosis.
出处
《河南医学研究》
CAS
2016年第2期199-202,共4页
Henan Medical Research
