摘要
目的探讨颅脑MRI在评价阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者认知功能异常中的临床价值。方法抽取放射科OSAHS患者75例进行回顾性分析,根据AHI指数分为轻度OSAHS组患者25例、中度OSAHS组患者25例、重度OSAHS组患者25例,并取体检中心25例正常患者样本作为对照组。分别计算各组患者的海马萎缩评分、PVH评分、MMSE评分、MoCA 评分,进行对比研究和相关性分析。结果不同严重程度OSAHS患者海马萎缩评分、PVH评分比较,重度OSAHS组海马萎缩评分、PVH评分高于中度OSAHS组、轻度OSAHS组和对照组;不同严重程度OSAHS患者MMSE评分、MoCA 评分比较,重度OSAHS组MMSE评分、MoCA 评分低于中度OSAHS组、轻度OSAHS组和对照组。海马萎缩评分、PVH与MMSE评分的相关性分析显示,海马体积萎缩、PVH与MMSE评分呈负相关。海马萎缩评分与MoCA 评分及其量子项目的相关性分析显示,海马体积萎缩与MoCA 评分、注意力、语言呈负相关。PVH与MoCA 评分及其量子项目的相关性分析显示,PVH与MoCA 评分、延迟记忆呈负相关。结论颅脑MRI的侧脑室周围高信号灶区域和海马萎缩检测结果对于OSAHS患者的认知功能具有一定的诊断价值,值得进一步研究。
Objective To explore the brain magnetic resonance imaging（MRI） in the evaluation of cognitive dysfunction in patients with OSAHS. Methods Seventy-five patients with OSAHS in radiology were retrospectively analyzed. According to AHI they were divided into the mild OSAHS group, the moderate OSAHS group and the severe OSAHS group, with each group twenty-five patients. Twenty-five patients from one health medical center were taken as the control group. Hippocampal atrophy scores, PVH score, MMSE score, MoCA score in defferent groups was compared and the correlation was analyzed. Results The hippocampal atrophy scores, PVH score in the severe OSAHS group was higher than that in the moderate OSAHS group,the mild OSAHS group and the control group. The MMSE score, MoCA score in the severe OSAHS group was below than that in the moderate OSAHS group, the mild OSAHS group and the control group. Hippocampal volume contraction, PVH was negatively correlated with MMSE score. Hippocampal volume contraction was negatively correlated with MoCA score, attention, language. PVH was negatively correlated with MoCA score and delayed memory. Conclusions Hippocampal atrophy and focal high signal area around lateral ventricle test from craniocerebral MRI results for cognitive function in patients with OSAHS has certain diagnostic value and deserves further research.
出处
《中国CT和MRI杂志》
2016年第5期9-12,共4页
Chinese Journal of CT and MRI
基金
海南省卫生厅2013年度医学科研课题(琼卫2013资助-065号)
关键词
阻塞性睡眠呼吸暂停低通气综合征
颅脑MRI
认知功能
Obstructive Sleep Apnea Hypopnea Syndrom
Brain Magnetic Resonance Imaging（MRI）
Cognitive Function
