摘要
精准医学是集合现代科技手段与传统医学方法,更加精准地诊断、治疗和评估个体患者的机能和疾病本质,以期用最有效、最安全和最经济的医疗服务,获取个体和社会健康效益最大化且风险最低化的理想医学范式。循证医学研究是验证相关诊治技术手段精准性的必要过程。本文阐述了精准医学概念及其与循症医学的关系,回顾了精准医学研究方法在脑血管疾病领域的应用现状,并指出现代遗传学技术、生物信息技术、分子影像技术、管理技术等为实现精准医学提供了技术手段,高质量的循证研究证据为精准医学临床实践提供了科学保证。精准医学是基于患者的基因信息、生活环境和临床数据等背景,为疾病的防治提供精准诊疗策略的个体化医疗模式,但其仍需在循证医学原则指导下经临床验证后才能广泛使用推广,因此,精准医学理想的实现需要长期探索与不懈努力。
Precision medicine is an ideal medical paradigm which combines modern scientific methods with traditional medical methods to diagnose, treat and evaluate the physical function and nature of diseases more precisely, and to maximize health benefits and minimize the risk of individuals and society with the most effective, safest, and the most economical medical service. Evidence-based medicine is necessary to verify the precision of diagnosis and treatment. In this review, we clarified the conception of precision medicine and the relation between precision medicine and evidence-based medicine. Moreover, we reviewed the application of precision medicine in the field of cerebrovascular disease. We pointed out that such new technologies as genetics, bioinformatics, molecular imaging and management provided tools to realize the idea of precision medicine, and high-quality evidence-based studies provided a guarantee for the clinical practice of precision medicine. In summary, precision medicine is an individualized medical mode that based on the context of a patient＇s genetic information, living environment and clinical data, etc. to provide precise treatment strategies for the prevention and treatment of disease, but still the promotion of precision medicine should be based on clinical validation under the guidance of evidence-based medicine. Thus, long-term exploration and unremitting efforts are required to achieve the idea of precision medicine.
出处
《中国循证医学杂志》
CSCD
2016年第4期373-377,共5页
Chinese Journal of Evidence-based Medicine
基金
四川省科技基础条件平台项目(编号:2012JCPT008)
关键词
精准医学
循证医学
脑血管病
Precision medicine
Evidence-based medicine
Cerebrovascular disease
