摘要
目的探讨尿胰蛋白酶抑制剂对严重脓毒症患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)和白细胞介素-10(IL-10)水平的影响。方法选取86例重度脓毒症患者为研究对象,采用随机数字表法将其分为实验组(43例),对照组(43例),2组患者均给予对症治疗,实验组在此基础上给予尿胰蛋白酶抑制剂静脉注射,比较2组患者治疗前后血清TNF-α、IL-8和IL-10水平的变化。结果治疗前2组患者血清TNF-α、IL-8和IL-10水平差异无统计学意义,治疗后2组患者TNF-α、IL-8水平均显著降低(P<0.05),IL-10水平显著升高(P<0.05),实验组改善水平高于对照组(P<0.05);实验组患者总有效率为86.05%显著高于对照组65.12%(P<0.05);治疗前2组患者的APACHE-II评分与认知功能评分差异无统计学意义,治疗后APACHE-Ⅱ评分显著降低(P<0.05),实验组显著低于对照组(P<0.05),治疗后认知功能评分显著升高(P<0.05),实验组显著高于对照组(P<0.05);实验组不良反应发生率2.33%,显著低于对照组20.93%(P<0.05)。结论尿胰蛋白酶抑制剂可以有效地改善重度脓毒症患者炎症因子水平,提高总有效率,降低APACHE-II评分,改善认知功能,减少不良反应。
Objective To explore the effect of urinary trypsin inhibitor on serum levels of tumor necrosis factor-α（ TNF-α）,interleukin-10（ IL-8）and interleukin-10（ IL-10） in patients with severe sepsis. Methods 86 cases of patients with severe sepsis were devided into experimental group（ with 43cases） and control group（ with 43 cases） by the random digital table method. The patients in the two groups were given symptomatic treatment,and the experimental group were given urinary trypsin inhibitor intravenous injection based on it. The changes of serum levels of TNF-α,IL-8 and IL-10 of the two groups before and after treatment were compared. Results There were no differences in serum levels of TNF-α,IL-8 and IL-10 between the two groups before treatment,among which the levels of TNF-α and IL-8 of the two groups after treatment were significantly decreased after treatment（ P〈0. 05）,while the levels of IL-10 were significantly increased（ P〈0. 05）. The improvement levels of the experimental group were higher than those of the control group（ P〈0. 05）. There were no differences in scores of APACHE-Ⅱ and cognitive function between the two groups before treatment,of which the scores of APACHE-Ⅱ of the two groups after treatment were significantly decreased（ P〈0. 05）,and the score of the experimental group was lower than that of the control group（ P〈0. 05）. The scores of cognitive function of the two groups after treatment were significantly increased（ P〈0. 05）,of which the experimental group was higher than that of the control group（ P〈0. 05）. The incidence rate of adverse reactions in the experimental group was2. 33%,which was significantly lower than that of 20. 93% in the control group（ P〈0. 05）. Conclusion Urinary trypsin inhibitor can effectively improve the levels of inflammatory factors in patients with severe sepsis,improve the total effective rate,reduce the APACHE-II score,improve cognitive function,and reduce adverse reactions.
出处
《中国生化药物杂志》
CAS
2016年第3期146-148,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
湖北省科学技术厅(EK2014D210006000852)
