摘要
目的观察急性胰腺炎患者经善宁联合乌司他丁治疗的临床效果。方法选取我院2014年3月至2015年9月收治的96例急性胰腺炎患者为研究对象,随机分为两组各48例。对照组单纯采用善宁治疗,观察组采用善宁和乌司他丁联合治疗。对比两组患者的临床治疗效果、不良反应和生化指标变化情况。结果观察组的总有效率为93.75%,明显高于对照组的77.08%;观察组休克、ARDS、急性肾炎、胃肠功能减退、肝功能衰竭和DIC的发生率均显著低于对照组;差异均有统计学意义(P<0.05)。经治疗,两组患者的白蛋白、WBC、血淀粉酶和APACHEⅡ等指标均显著改善,且观察组改善程度明显优于对照组,差异具有统计学意义(P<0.05)。结论急性胰腺炎患者经善宁联合乌司他丁治疗效果显著,还可缓解临床症状,有效控制不良反应和并发症的发生,具有较高的临床应用价值。
Objective To observe the clinical effect of sandostatin combined with ulinastatin in treatment of patients with acute pancreatitis. Methods 96 cases of patients with acute pancreatitis treated in our hospital from March 2014 to September 2015 were selected and randomly divided into two groups, with 48 cases in each group. The control group was given simple sandostatin, the observation group was given sandostatin combined with ulinastatin. The clinical effect, adverse reactions and changes of biochemical indices were compared between two groups. Results The total effective rate of observation group was 93.75%, significantly higher than 77.08% of control group; the incidence of shock, ARDS, acute nephritis, gastrointestinal dysfunction, hepatic failure, DIC in observation group were significantly lower than those in control group; all the difference was statistical （P〈0.05）. After treatment, the levels of albumin, WBC, serum amylase and APACHE II of two groups improved significantly, and the improvement degree of observation group was better than that of control group, with statistical difference （P 〈0.05）. Conclusions Sandostatin combined with ulinastatin has significant effect in treatment of acute pancreatitis patients, and can relieve clinical symptoms, effectively control the occurrence of adverse reactions and complications, which also has higher clinical application value.
出处
《临床医学工程》
2016年第4期495-496,共2页
Clinical Medicine & Engineering
关键词
善宁
乌司他丁
急性胰腺炎
临床效果
Sandostatin
Ulinastatin
Acute pancreatitis
Clinical effect
