摘要
体内多种细胞表达不同类或亚类Ig的Fc受体,它们在促进和调节免疫方面起着重要作用,FcγRⅡB是体内唯一的抑制性Fcγ受体,越来越多的研究表明,FcγRⅡB在自身免疫性疾病的发病中起着重要作用,如系统性红斑狼疮、类风湿关节炎。多项研究表明,细胞表面活化性与抑制性Fcγ受体比例的失调也将导致多种疾病的发生,FcγRⅡB能下调活化性Fcγ受体介导的吞噬、免疫复合物诱导的炎症和相关细胞炎性因子的释放。因此,阐明其与疾病间的联系,将有助于为自身免疫性疾病提供新的治疗策略。
There are a variety of cells that could express different kinds or types of Ig Fc receptors,and they play an important role in promoting and regulating immune response, but FcγR Ⅱ B is the only inhibitory receptor. A growing number of studies have shown that FcγRⅡB plays an important role in the pathogenesis of autoimmune diseases,such as systemic lupus erythematosus,rheumatoid arthritis. Several studies have shown that keep the balance between activating and inhibitory Fcγreceptor is very important,othernise,it will lead to many diseases, and FcγR Ⅱ B can inhibits the function of activating FcγRs, such as phagocytosis,the inflammation induced by immune complex and the release of pro-inflammatory cytokins. Therefore,to clarify the relationship between FcγRⅡB and diseases,will be helpful to provide new treatment strategies for autoimmune diseases.
出处
《中华临床免疫和变态反应杂志》
2016年第1期69-74,共6页
Chinese Journal of Allergy & Clinical Immunology
