摘要
目的应用Meta分析法系统评价中西医结合治疗腹腔间隔室综合征（ACS）的临床疗效。方法计算机检索中国知网CNKI、中文科技期刊数据库（VIP）、万方数据库、中国生物医学文献数据库（CBM）数据库、美国国立医学图书馆PubMed数据库、WebofScience和Cochrane临床试验数据库中2004年1月至2015年8月发表的有关中西医结合与单纯西医治疗ACS的随机对照试验（RCT）。观察指标为存活率、肠呜音恢复情况、IAP降低情况、ICU住院天数、排便情况。使用CochraneRCT偏倚风险评估工具对纳入研究进行方法学质量评价，并使用RevMan5．3软件进行统计分析。结果共纳入10项研究，454例ACS患者。Meta分析结果显示：中西医结合治疗组在提高患者存活率[优势比（OR）=3．21，95％可信区间（CI）：（1．64，6．27），P=0．0007J、恢复肠鸣音[MD=-1．73，95％CI=（-2．06，-1．39），P〈0．00001]、降低腹内压【MD=5．96，95％CI=（3．82，8．10），P〈0．00001]、缩短ICU住院时间[均数差（MD）=-11．19，95％CI=（-12．64，-9．75），P〈0．00001]、改善排便情况[MD=-1．18，95％CI=（-1．97，-0．40），P=0．003]方面效果优于纯西医治疗对照组，差异均有统计学意义。结论Meta分析结果表明，中西医结合治疗较单用西医治疗ACS有更好的临床疗效，但由于纳入试验的研究方法有待改进以及文献质量不高，所以需要更多的RCT加以证实。
Objective To systemically evaluate clinical therapeutic efficacy of integrated traditional Chinese and western medicine in treating patients with abdominal compartment syndrome （ACS） with Meta analysis. Methods Databases including CNKI, VIP, Wanfang Data, CBM, PubMed, Web of Science, Coehrane library were searched to identify randomized controlled trials （RCT） regarding integrated traditional Chinese and western medicine and simple western medicine in treatment of ACS published from January 2004 to August 2015. The quality of the included RCT was assessed by using Coehrane collaboration stool for evaluating the risk of bias, survival rate, recovery of bowel sound, reduce intra-abdominal pressure, the ICU hospitalization time, defection were observed, and statistieal analysis was performed by using the software RevMan 5.3. Results According to the inclusion criteria, 10 articles were included in this study involving totally 454 patients with ACS. The results of Meta-analyses showed that the therapeutic efficacy of integration of traditional Chinese and western medicine was superior to that of simple western medicine for treatment of the patients in the following aspects： increasing the patients＇ survival rate [odds ratio （OR） = 3.21, 95% confidence interval （95%CI） = （1.64, 6.27）, P = 0.000 7], recovery of bowel sound [mean difference （MD） = -1.73, 95%CI = （-2.56, -1.39）, P 〈 0.000 01], reducing intra-abdominal pressure [MD = 5.96, 95%CI = （3.82, 8.10）, P 〈 0.000 01], shortening the ICU hospitalization time [MD = -11.19, 95%CI = （-12.64, -9.75）, P 〈 0.000 01], and improving defecation [MD = -1.18, 95%CI = （-1.97, -0.40）, P = 0.003], the differences being statistically significant. Conclusion The results of Meta-analyses showed that the clinical curative effect of integrated traditional Chinese and western medicine in treatment of patients with ACS is better than that of pure western medicine, but due to the inclusion of experimental research methods should be impro
出处
《中国中西医结合急救杂志》
CAS
北大核心
2016年第2期138-142,共5页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
卫生部国家临床重点专科建设项目（2011-873）
关键词
腹腔间隔室综合征
中西医结合治疗
META分析
Abdominal compartment syndrome
Integration of traditional Chinese and western medicinelherapy
Meta-analysis
