摘要
目的:观察在常规治疗基础上予益气活血经验方内服联合丹红注射液对冠心病介入术后心肌缺血再灌注损伤的保护作用。方法:选取76例冠心病介入术后心肌缺血患者,随机分为对照组和治疗组各38例。2组患者均给予抗凝、扩张冠状动脉、营养心肌等基础治疗,对照组加用丹红注射液治疗,治疗组给予益气活血经验方内服联合丹红注射液治疗,2组均连续用药1月。比较2组的临床疗效,监测心肌损伤指标血清肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)、心肌肌钙蛋白(c Tn I)水平的变化。结果:治疗组总有效率为92.1%,高于对照组的总有效率(71.1%),差异有统计学意义(P<0.05)。术后24 h,2组血清CK-MB、BNP、c Tn I水平均高于术前(P<0.05),治疗组各指标水平均低于对照组(P<0.05);术后72 h,2组3项指标均较术后24 h下降(P<0.05),治疗组各指标水平均低于对照组(P<0.05)。结论:在常规治疗基础上加用益气活血经验方内服联合丹红注射液利于减轻冠心病介入术后心肌缺血的再灌注损伤,减少术后的缺血改变,强化心肌保护。
Objective：To observe the protective effect of Huoxue Yiqi empirical formula to be taken orally combined with danhong injection on reperfusion injury of myocardial ischemia after percutaneous coronary intervention based on conventional medical treatments. Methods： Seventy- six cases of patients with myocardial ischemia after percutaneous coronary intervention were divided randomly into the control group and the treatment group,38 cases in each group. All patients in both groups were given the basis treatment such as anti- freezing,dilating coronary artery and cardio tonic etc. The patients in the control group were treated with danhong injection,and the patients in the treatment group were treated with Huoxue Yiqi empirical formula to be taken orally combined with danhong injection. The treatment in both groups were all lasted a month continually. Compared the clinical effect in both groups,detected the level changes of myocardial damage indexes including serum creatine kinase- mb（CK- MB）,brain natriuretic peptide（BNP） and cardiac troponin（c Tn I）. Results：The total effective rate of the treatment group was 92.1%, which was higher than that of the control group of 71.1%（P 〈0.05）. At 24 h after operation,the levels of serum CK- MB,BNP and c Tn I in both groups were all higher than those before operation（P〈0.05）,and the levels of every index in the treatment group were all lower than those in the control groups（P〈0.05）. At 72 h after operation,all indexes levels in both groups were all dropped（P〈0.05 compared with those at 24 h after operation）,and the levels of every index in the treatment group were all lower than those in the control group（P〈0.05）. Conclusion：The addition of Huoxue Yiqi empirical formula to be taken orally combined with danhong injection on the base of conventional medical treatment can be beneficial to reduce the reperfusion injury of myocardial ischemia after percutaneous coronary intervention,relieve ischemic changes after operation and strengt
出处
《新中医》
CAS
2016年第4期23-25,共3页
New Chinese Medicine
关键词
冠心病
经皮冠状动脉介入术(PCI)
心肌缺血
再灌注
气虚瘀阻证
中西医结合疗法
益气活血经验方
丹红注射液
Percutaneous coronary intervention
Myocardial ischemia
Reperfusion
Qi-deficiency and stagnation syndrome
Integrated Chinese and western medicine therapy
Huoxue Yiqi empirical formula
Danhong injection
