摘要
目的探讨静脉及鞘内联合应用万古霉素治疗患者术后颅内感染的临床效果,为临床治疗提供参考依据。方法选取2013年3月-2015年3月医院开颅术后发生颅内感染患者33例,其中静脉注射抗菌药物联合鞘内注射万古霉素抗感染治疗患者18例作为观察组,仅进行静脉注射抗菌药物治疗的15例患者作为对照组;对比两组患者治疗效果,数据采用SPSS 19.0软件进行统计分析。结果治疗3d后观察组患者脑脊液白细胞、葡萄糖、蛋白定量较治疗前明显好转,与对照组相比差异无统计学意义;观察组患者治疗总有效率为94.4%,明显高于对照组的73.3%,差异有统计学意义(P<0.05)。结论鞘内注射操作简便、创伤小,能使药物不经血脑屏障直接进入蛛网膜下腔,脑脊液中药物浓度高,效果好。
OBJECTIVE To investigate the clinical effect of combined application of vancomycin in the treatment of intracranial infections after craniotomy,and to provide basis for clinical treatment.METHODS A total of 33 cases of intracranial infections after craniotomy selection from Mar.2013 to Mar.2015 were chosen.They were divided into observation group and control group.Among them 18 cases were applied with intrathecal injection of vancomycin in the treatment of intravenous antibiotics,and 15 patients applied with intravenous antibiotics were treated as the control group.The therapeutic effects of the two groups were compared.The results were statistically analyzed by software SPSS 19.0.RESULTS After three days of treatment,patients in the observation group were significantly improved in the treatment of cerebrospinal fluid leukocyte,glucose level,protein quantitative compared with prior treatment.There was no significant differeuce.The total effective rate of the significeatly group was94.4% which was significantly higher than that of the control group with 73.3%（P〈0.05）.CONCLUSIONThe internal injection is simple and less traumatic,which can make the drug get rid of blood-brain barrier and go directly into the subarachnoid space.The concentration of drug in the cerebrospinal fluid is high,and it is effective.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第7期1569-1571,共3页
Chinese Journal of Nosocomiology
基金
浙江省医药卫生科技计划基金资助项目(2014KYA203)
关键词
鞘内注射
万古霉素
开颅术
颅内感染
Intrathecal injection
Vancomycin
Craniotomy
Intracranial infection
