摘要
目的通过对难治性癫患儿进行生酮饮食,检测生酮饮食前后免疫功能各项指标的变化,分析生酮饮食对小儿难治性癫免疫功能的影响。方法选取该院36例癫患儿为观察组,给予生酮饮食;选取36例健康儿童为对照组;观察组生酮饮食前、饮食后1个月、3个月、6个月、12个月各采血1次;对照组儿童仅采血1次。采集空腹静脉血,测血清IgA、IgG、IgM及CD3、CD4、CD8。结果生酮饮食前,相对于正常儿童,难治性癫患儿IgA、IgG、CD8含量升高,CD3、CD4下降,差异有统计学意义(P<0.05)。相对于生酮饮食前,生酮饮食后3个月患儿IgA、IgG、CD8含量显著下降,CD3、CD4显著升高,差异有统计学意义(P<0.05),与正常儿童比较差异无统计学意义(P>0.05)。结论难治性癫患儿存在细胞免疫、体液免疫功能的紊乱,生酮饮食治疗后3个月免疫功能得到明显改善,癫发作得到有效控制,可能是生酮饮食治疗难治性癫的机制之一。
Objective To study the influence of ketogenic diet on immune function of children with intractable epilepsy by testing immune index.Methods Totally 36 cases of children with refractory epilepsy were selected from to the hospital as the observation group,other 36 cases of health check-up children were as the control group.Serum immunoglobulin IgA,IgG,IgM and CD3,CD4,CD8 were measured before the ketogenic diet,diet after 1 month,3 months,6 months,12 months each blood 1 time,respectively;but the control group of children got the blood once only.Results Before ketogenic diet,IgA,IgG,CD8 content in children with intractable epilepsy were increased,but CD3,CD4 content decreased,there were significant difference compared with normal control group（P〈0.05）.Ketogenic diet after 3 months with IgA,IgG,CD8 levels were continue to decline,CD3,CD4 continue to rise the comparative differences were significant（P〈0.05）,there was no significant difference compared with normal control group（P〈0.05）.Conclusion Ketogenic diet after 3 months can dramatically improve immune function,effectively control seizures,and perhaps the ketogenic diet may be one of the mechanisms of intractable epilepsy.
出处
《中国煤炭工业医学杂志》
2016年第3期351-353,共3页
Chinese Journal of Coal Industry Medicine
基金
2014年度河北省医学科学研究重点课题计划(编号:ZD20130080)
关键词
儿童
生酮饮食
难治性癫痫
免疫功能
Children
Ketogenic diet
Intractable epilepsy
Immune function
