摘要
目的研究甲状腺激素在高脂血症性急性胰腺炎患者中的变化和其对疾病严重程度的预测价值。方法选择2012年1月至2014年7月某院高脂血症性急性胰腺炎患者46例,根据疾病严重程度分为轻度急性胰腺炎和中度急性胰腺炎。检测生化肝肾功能和血脂,检测甲状腺激素指标包括游离三碘甲状腺原氨酸、总三碘甲状腺原氨酸、游离甲状腺素、总甲状腺素和促甲状腺激素。结果轻度急性胰腺炎患者的游离三碘甲状腺原氨酸、总三碘甲状腺原氨酸和促甲状腺激素均明显高于中度急性胰腺炎患者。总三碘甲状腺原氨酸、总甲状腺素和促甲状腺激素均与甘油三脂呈负相关(r分别为-0.325、-0.482和-0.328,P分别为0.027、0.001和0.026)。游离三碘甲状腺原氨酸是高脂血症性急性胰腺炎出现中度急性胰腺炎的危险因素。结论甲状腺激素水平随高脂血症性急性胰腺炎病情加重而降低,促甲状腺激素下降与甘油三脂升高有关,游离三碘甲状腺原氨酸可以作为早期预测高脂血症性急性胰腺炎严重程度的指标。
Objective To profile thyroid hormone（TH） change and predictive value of disease severity in patients with hyperlipidemic acute pancreatitis（HLAP）. Methods From Jan 2012 to Jun 2014, total 46 HLAP patients admitted to our hospital were enrolled. Patients were divided into 2 groups by disease severity： mild acute pancreatitis（MAP） and moderately severe acute pancreatitis（MSAP）. Assay including function of liver and kidney,blood lipids. Also TH index assay, including free tri-iodothyronine（FT3）, total tri-iodothyronine（TT3）, free thyroxine, total thyroxine（TT4） and thyroid stimulating hormone（TSH）.Results FT3, TT3 and TSH were progressively decreased in MSAP compared with those in MAP. TT3, TT4 and TSH were negative correlation with triglycerides（TG）（r=-0.325,-0.482, and-0.328, P=0.027, 0.001, and 0.026, respectively）. FT3 was a risk factor for MSAP in HLAP patients. Conclusions TH is decreased with severity of HLAP. Deceased TSH is correlation with increased TG.FT3 is a robust indicator for early assessment of the severity in HLAP patients.
出处
《中国病案》
2016年第2期93-96,共4页
Chinese Medical Record
基金
首都医科大学2015年度本科生科研创新项目(XSKY2015170)
