摘要
目的联合彩色多普勒超声对恩替卡韦、复方丹参滴丸治疗失代偿期乙型肝炎肝硬化疗效进行评价。方法将38例慢性乙型肝炎失代偿期肝硬化患者随机分为治疗组与对照组,各19例,2组均采用营养支持、保肝、利尿、抗感染等治疗,对照组加恩替卡韦0.5 mg/次,空腹口服,1次/d,观察组在上述治疗基础上加服复方丹参滴丸10丸/次,3次/d,2组均12周为1个疗程,共4个疗程。于治疗前及治疗后12、24、48周行肝功能ALT、AST、ALB、TBIL检测,采用彩色多普勒超声检测门、脾静脉血管内径、平均血流速度,并计算门、脾静脉血流量。结果治疗12、24、48周,肝功能ALT、AST、ALB、TBIL各项指标均有所恢复,观察组优于对照组,P<0.05;治疗12、24、48周,血流动力学各项指标均有所恢复,观察组优于对照组(P<0.05)。结论恩替卡韦联合复方丹参滴丸可有效改善失代偿期乙型肝炎肝硬化患者肝功能,改善门、脾静脉血流动力学,彩色多普勒超对判断肝功能、指导用药、病情及预后评估有重要参考价值。
Objective To evaluate the efficacy and clinical value of compound Danshen dripping pills and entecavir in combined with color Doppler ultrasound in the treatment of decompensated liver cirrhosis of hepatitis B. Methods The clinical materials of 38 patients with decompensated liver cirrhosis of chronic hepatitis B were retrospectively analyzed. The patients in the two groups were given nutrition support,liver protection,diuretics,and anti-infection.The patients in the control group were orally given entecavir,0. 5mg / time,1 time / d. On this basis,the patients in the observation group were given additional compound Danshen dripping pills,10 pills / time,3 times / d. Twelve-week treatment was regarded as one course,and 4 course were involved. The levels of ALT,AST,ALB,and TBIL were detected before treatment,12,24,48 weeks after treatment. Color Doppler ultrasound was used to detect the inner diameter of portal and splenic veins,and the average blood flow rate. Then,the blood flow volume of portal and splenic veins was calculated. Results The comparison of the levels of ALT,AST,ALB,and TBIL before treatment between the two groups was not statistically significant( P〈0. 05). With the treatment timing extending,the various indicators of liver function were recovered,which were significantly superior in the observation to those in the control group( P〈0. 05).The comparison of the inner diameter,blood flow rate,and blood flow volume of portal and splenic veins before treatment between the two groups was not statistically significant( P〉0. 05). With the treatment timing extending,the various indicators of hemodynamics were recovered,which were significantly superior in the observation to those in the control group( P〈0. 05). Conclusion Entecavir in combined with compound Danshen dripping pills can effectively improve the liver function in patients with decompensated liver cirrhosis of hepatitis B,and the hemodynamics of portal and splenic veins. Color Doppler ultrasound can accurately measure the
出处
《长春中医药大学学报》
2016年第2期341-343,共3页
Journal of Changchun University of Chinese Medicine
基金
河北省张家口市计划外科研课题(2016023)
关键词
彩色多普勒超声
恩替卡韦
复方丹参滴丸
失代偿期乙型肝炎肝硬化
color Doppler ultrasound
entecavi
compound Danshen dripping pills
decompensated liver cirrhosis of hepatitis B