摘要
目的观察α硫辛酸联合单唾液酸四己糖神经节苷脂（以下简称神经节苷脂）治疗糖尿病周围神经病变（DPN）患者的效果及对相关神经传导速度的影响。方法将纳入研究的96例DPN患者随机分为观察组50例和对照组46例。对照组在常规治疗基础上每日给予神经节苷脂40mg静脉滴注；观察组在对照组的基础上每日给予α-硫辛酸600mg静脉滴注。两组疗程均为2周。治疗2周后观察疗效，并行肌电图检查测定正中神经、腓总神经的运动神经传导速度（MNCV）和感觉神经传导速度（SNCV）。结果观察组总有效率94．00％（47／50）高于对照组71．74％（33／46），差异有统计学意义（χ2=7．021，P〈0．05）；治疗后，观察组与对照组患者正中神经的MNCV[（47．68±3．34）、（43．82±3．10）m／s]、SNCV[（40．23±2．76）、（37．31±2．79）m／s]与腓总神经的MNCV[（42．86±3．16）、（39．47±2．17）m／s]、SNCV[（35．67±2．61）、（32．16±2．50）m／s]均较治疗前改善，与治疗前比较差异均有统计学意义（观察组治疗前后比较，t值分别为7．876、8．428、6．923、7．234；对照组治疗前后比较，t值分别为3．572、3．483、3．413、4．182，P均〈0．05），但观察组改善更明显，与对照组治疗后比较差异有统计学意义（t值分别为5．133、3．827、4．634、4．546，P均〈0．05）。结论仅．硫辛酸联合神经节苷脂治疗DPN可显著改善患者临床症状及提高相关神经传导速度，优于单用神经节苷脂。
Objective To observe the therapeutic effect and effects on nerve conduction velocity of The therapeutic effect and effects on nerve conduction velocity of α-lipoic acid combined with monosialoteterahexosyl ganglioside sodium on diabetic peripheral neuropathy- lipoic acid combined with monosialoteterahexosyl ganglioside sodium（ GM1 ） on diabetic peripheral neuropathy （DPN）. Methods Ninety-six cases patients with DPN were randomly divided into the observation group （50 cases ） and the control group （46 cases）. The control group received GM 1 40 mg daily though travenous drip, the observation group received The therapeutic effect and effects on nerve conduction velocity of α-lipoic acid combined with monosialoteterahexosyl ganglioside sodium on diabetic peripheral neuropathy-lipoic acid 600 mg and daily though travenous drip. The course of treatment was 2 weeks in two groups. The effect was observed after 2 weeks, the motor nerve conduction velocity （ MNCV ） and sensory nerve conduction velocity （ SNCV ） of median nerve and common peroneal nerve were detected by EMG. Results The total effectiveness of observation group was 94.00% （47/50） ,higher than that of the control group（71.74%（ 33/46）, χ2= 7. 0205, P〈0. 05 ）. After the treatment, MNCV and SNCV of median nerve of observation group and the control group were （47. 68±3.34） m/s and （43.82±3.10）m/s, （40. 23±2. 76）m/s, （ 37. 31 ± 2. 79） m/s, and MNCV and SNCV of common peroneal nerve of observation group and the control group were （42. 86± 3.16） rn/s and （ 39.47 ±2. 17 ） m/s, （ 35.67 ± 2. 61 ） rn/s and （ 32. 16 ±2. 50 ） m/s, all improved compared to before treatment（ observation grou ： t = 7. 876,8. 428,6. 923,7. 234; control grou ： t = 3. 572,3. 483, 3.413,4. 182;P〈0. 05 ） , and the magnitude of improvement of the observation group was more significant, and the difference was significant compared to control group after six months （t = 5. 133,3. 827,4. 634,4. 545; P 〈0. 05
出处
《中国综合临床》
2016年第3期231-234,共4页
Clinical Medicine of China
