摘要
细胞分裂周期蛋白42(cell division cycle 42,CDC42)是Rho蛋白鸟苷三磷酸酶(guanosine triphosphatase,GTPase)家族成员之一,在细胞增殖、迁移、转化等过程发挥重要作用。与大多数GTPase一样,CDC42的活性受到鸟嘌呤核苷酸转换因子(guanine nucleotide exchange factors,GEF)、GTP酶激活蛋白(GTPase activating proteins,GAP)和鸟苷酸解离抑制因子(guanine nucleotide-dissociation inhibitors,GDI)的调控。目前研究表明,CDC42在大多数人癌症组织中表达异常,对癌症的发生发展具有复杂而重要的调控作用。该文就CDC42自身活性变化、CDC42调节因子的变化及其下游效应因子的变化在癌症中的作用进行综述,旨在深入理解CDC42在人类癌症中的作用机制。
Cell division cycle 42（ CDC42） is a member of Rho guanosine triphosphatase（ GTPase） family,which plays an important role in cell proliferation,cell migration and cell transformation. The activity of CDC42 can be regulated by guanine nucleotide exchange factors（ GEFs）,GTPase activating proteins（ GAPs） and guanine nucleotide-dissociation inhibitors（ GDIs）. Recently,CDC42 has been reported as abnormally expressed in many human cancers,suggesting that CDC42 performs complex functions in tumorigenesis. Therefore,this paper aims to shed light on the functions of CDC42 in cancers in terms of the alteration of CDC42 activity,CDC42 regulators,as well as its effectors.
出处
《军事医学》
CAS
CSCD
北大核心
2016年第3期256-260,共5页
Military Medical Sciences
基金
国家重点基础研究发展计划(2011CB910600
2013CB911200)
国家自然科学基金资助项目(31470809
31170780)
北京市自然科学基金资助项目(5152008)
