摘要
目的:观察大定心汤对阿尔茨海默病的临床疗效,初步探寻大定心汤治疗阿尔茨海默病的作用机制及安全性,为下一步试验奠定理论研究基础。方法:将阿尔茨海默病患者随机分成对照组和治疗组,对照组参照《老年性痴呆诊断治疗指南》标准治疗,本次研究采用盐酸多奈嘛齐作为对照药物,治疗组采用大定心汤治疗。观察两组患者年龄和病程的比较情况,对比两组治疗前后MMSE积分、ADL评分的改变情况。同时检查血常规、尿常规、大便常规、心肝肾功能等作为安全性评价的指标。结果:观察组总有效率为76.7%,对照组总有效43.3%,说明大定心汤的疗效优于盐酸多奈嘛齐。结论:大定心汤能在一定程度上减少AD患者痛苦,提高患者晚年生活质量。两组在临床服药观察过程中未发现不良反应,安全系数高,大定心汤是目前临床在治疗阿尔茨海默病方面的一种全新的尝试,值得积极研究和推广使用。
Objective：To observe the Dadingxin Decoction of the clinical curative effect of alzheimer＇s disease,a preliminary explore the centering mechanism of action of decoction in the treatment of alzheimer＇s disease and security,test theory basis for the next step. Methods：Alzheimer＇s patients were randomly divided into control group and treatment group,control group with reference to the senile dementia to guide the diagnosis and treatment standard treatment,this study using hydrochloric acid to endure more neat as controlled drugs,the treatment group adopted the therapy Dadingxin Decoction. Observe the comparison of two groups of patients age and course of the disease,compared two groups of the change of the MMSE score,ADL scores before and after the treatment. At the same time check the blood routine,urine routine,stool routine,as a safety evaluation indexes such as heart function. Results：The total effective rate was 76.7%,observing group,control group total effective 43.3%,shows that the curative effect of DadingxinDecoction is better than that of hydrochloric acid to endure more neat. Conclusion：Dadingxin Decoction can have a certain extent,reduce pain in patients with AD,improve the quality of the patients in later life. In the process of the two groups in clinical medication observation found no adverse reaction,high safety coefficient,Dadingxin Decoction is currently in the treatment of alzheimer＇s disease clinical aspects of a new attempt,is worthing actively researching and promotion using.
出处
《辽宁中医药大学学报》
CAS
2016年第4期209-211,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
大定心汤
阿尔茨海默病
临床疗效
Dadingxin Decoction
alzheimer＇s disease
clinical observation
