摘要
目的调查不良结局家族聚集性HBV感染家系的家庭成员间HBV传播特点以及父母HBsAg状态不同时子代HBsAg流行与分布特点。方法对2007-2010年间收集的不良结局家系的每位成员进行一般信息登记及血清学检测，分析家庭成员间HBsAg流行分布情况。对266个核心家系中父母亲HBsAg状态不同时，子代性别及HBsAg流行情况进行比较分析。结果先证者父母、同胞、子女、配偶中HBsAg阳性率分别为20％、88．2％、76．8％、9．5％。父亲HBsAg阳性母亲HBsAg阴性核心家系中子代男性比例显著升高（男性：女性=2．02），显著高于母亲HBsAg阳性父亲HBsAg阴性（1．22）或父母HBsAg均阳性（0．96）的核心家系；另外，父亲HBsAg阳性母亲HBsAg阴性的核心家系中子代男性HBsAg阳性率（37．4％）显著高于女性（13．8％），在母亲HBsAg阳性父亲HBsAg阴性或父母HBsAg均阳性的核心家系中子代不同性别间HBsAg阳性率无差异。结论在不良结局家族聚集性HBV感染家系中，母婴传播仍然是HBV感染的主要传播途径，但是父婴传播在该特殊人群的HBV传播中也发挥一定作用。父亲HBsAg阳性可能与子代男性比例升高相关，并且HBV在父-子间传播中显著高于父-女间传播。
Objective To investigate the characteristics of hepatitis B virus （HBV） transmission among family members in families with familial clustering of HBV infection and poor outcomes, as well as the prevalence and distribution characteristics of HBsAg in offspring with different parental HBsAg status. Methods The general information of each member in families with poor outcomes were collected from 2007 to 2010, andserological test was performed to analyze the prevalence and distribution of HBsAg in family members. The chi-square test or Fisher＇s exact test was used to analyze and compare the sex of offspring and the prevalence of HBsAg in them in 266 nuclear families with different paternal and maternal HBsAg status. Results The positive rates of HBsAg in parents, siblings, children, and spouses of the probands were 20%, 88.2%, 76.8%, and 9.5%, respectively. The nuclear families with HBsAg-positive fathers and HBsAg-negative mothers had a significantly increased proportion of male offspring （male/female ratio = 2.02） compared with those with HBsAg-positive mothers and HBsAg-negative fathers （1.22） or those with HBsAg-negative fathers and mothers （0.96）. In addition, in the nuclear families with HBsAg-positive fathers and HBsAg-negative mothers, the male offspring had a significantly higher HBsAg positive rate than female offspring （37.4% vs 13.8%）, while in those with Hl3sAg-positive mothers and HBsAg-negative fathers or those with HBsAg-negative fathers and mothers, HBsAg positive rate showed no significant difference between male and female offspring. Conclusion In families with familial clustering of HBV infection and poor outcomes, mother-to-child transmission is still the major route of HBV transmission, but father-to-child transmission also plays a role in HBV transmission in this special population. Positive HBsAg in fathers is associated with the increased proportion of male offspring, and father-to-son transmission of HBV is higher than father-to-daughter transmission.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2016年第4期246-251,共6页
Chinese Journal of Hepatology
基金
基金项目：国家“十二五”传染病重大专项（2012ZX10002007001）
陕西省科技攻关项目（2014k11-03-03-09）
