摘要
目的探讨血清N端B型脑钠肽前体（NT-proBNP）水平与急性胰腺炎（AP）患者病情严重程度及预后的相关性。方法检测93例AP患者发病48小时内及治疗后血清中NT-proBNP水平，并评估Ranson、APACHEⅡ、MarshaⅡ分值，将其分为轻度急性胰腺炎（MAP）组23例，中度急性胰腺炎（MSAP）组44例，重度急性胰腺炎（SAP）组26例，同时选取42例健康体检者作为对照组，比较各组血清NT-proBNP水平。结果AP组与对照组血糖、NT—proBNP水平、左心室射血分数（LVEF）、C反应蛋白（CRP）比较差异有统计学意义（P〈0．05）。MAP组患者血清NT-proBNP水平在人院时[（44．74±15．22）pg／ml]和治疗后[（42．19±17．46）pg／ml]比较差异无统计学意义（P〉0．05）；MAP组血清NT—proBNP水平[（42．19±17．46）pg／ml]与对照组[（41．48±14．73）pg／ml]比较，差异无统计学意义（P〉0．05）；MSAP组患者血清NT—proBNP水平在入院时[（322．78±172．26）pg／ml]和治疗后[（178．53±103．16）pg／ml]比较差异有统计学意义（P〈0．05）；SAP组患者血清NT-proBNP水平在人院时[（1110．88±889．59）pg／ml]和治疗后[（631．20±843．78）pg／ml]比较差异有统计学意义（P〈0．05）；3组患者组间NT—proBNP水平比较，分别在入院时和治疗后比较差异有统计学意义（P〈0．05）。AP组患者血清NT-proBNP水平与Ranson（r=0．667，P〈0．05）、APACHER（r=0．770，P〈0．05）、MarshaⅡ（r=0．740，P〈0．05）评分均呈正相关。结论血清NT-proBNP水平在中、重度AP时升高，并且与病情严重程度相关，可及时有效评估AP患者心功能障碍情况。
Objective To assess the relationship between serum N-terminal pro-brain natriuretic peptide（NT-proBNP） concentrations and severity of acute pancreatitis （AP）. Methods 93 patients with AP were included in this study. NT-proBNP measurements were performed in all patients within 48 hours of disease onset and after treatments. According to Ranson, APACHE Ⅱ and Marshall scoring systems, patients were divided into 3 groups： mile acute pancreatitis （MAP） group with 23 patients moderately severe acute pancreatitis（MSAP） group with 44 patients, and severe acute pancreatitis（SAP） group with 26 patients. Choosing 42 cases of healthy volunteers （ control group）. NT-proBNP concentrations between groups were compared. Results The blood glucose, NT-proBNP, LVEF, CRP in AP group were significantly different with control group（ P 〈 0. 05）. There was no difference of NT-proBNP between MAP group [ （42. 19 ±17.46）pg/ml ] and control group [ （41.48 ± 14. 73 ）pg/ml ], P 〉 0. 05. Serum NT-proBNP levels of MAP group on admission and after treatment were （ 44. 74 v 15.99） pg/ml and （ 42. 19 ±17.46 ） pg/ml, respectively（P 〉 0. 05 ）. But MSAP group were （322.78 ± 172. 26） pg/ml and （ 178.53 ± 103. 16） pg/ml and SAP group were （ 1 110. 88 ±889. 59） pg/ml and （631.20± 843. 78 ） pg/ml, respectively （ P 〈 0.05 ）. Serum NT-proBNP levels were significantly different among the 3 groups on admission and after treatments（P 〈0.05）. Increased serum NT-proBNP levels were positively correlated with severity of the disease determined by Ranson（r =0.667,P 〈0.05） ,APACHE Ⅱ （r =0.770,P 〈0.05） and Marshall （r =0. 740,P 〈 0.05） scoring systems. Conclusion Increased serum NT-proBNP levels might be a plausible indicator of severity of AP during the course of the disease.
出处
《临床内科杂志》
CAS
2016年第3期189-191,共3页
Journal of Clinical Internal Medicine
关键词
N端B型脑钠肽前体
急性胰腺炎
病情程度
心功能
N-terminal pro-brain natriuretic peptide
Acute pancreatitis
Disease progression
Cardiac function
