摘要
目的：对侵袭性胸腺瘤病例 Axin 与β-catenin 表达进行研究分析，为临床指导诊断、治疗及预后等提供依据。方法将2013年1月至2014年10月胸外科经 CT 诊断及手术病理检验后确诊为胸腺瘤的112例患者根据 Masaoka 分期方法分为非侵袭性组52例（Ⅰ期）和侵袭组60例（Ⅱ~Ⅳ期），其中Ⅱ期52例，Ⅲ期6例，Ⅳ期2例。均行组织样本免疫组化法检测，比较 Axin 与β-catenin 阳性情况。结果侵袭性胸腺瘤的 Axin 阳性表达率为93.3％（56/60），显著高于非侵袭性胸腺瘤的57.7％（30/52），差异有统计学意义（χ2=10.692，P ﹤0.01）；侵袭性胸腺瘤患者中Ⅱ期 Axin 阳性表达率为50.0％（26/52），Ⅲ期为66.7％（4/6），Ⅳ期为100％（2/2），三组比较差异未见统计学意义（χ2=2.411，P ﹥0.05）。侵袭性胸腺瘤的β-catenin 阳性表达率为93.3％（56/60），显著高于非侵袭性胸腺瘤的57.7％（30/52），差异有统计学意义（χ2=1.852，P ﹤0.01）；侵袭性胸腺瘤患者中Ⅲ期的β-catenin 阳性表达率均为100％（6/6），Ⅳ期为100％（2/2），Ⅱ期为92.3％（48/52），差异有统计学意义（χ2=15.070，P ﹤0.01），两两比较差异未见统计学意义（P ﹥0.05）。结论 Axin 与β-catenin 在侵袭性胸腺瘤患者中较非侵袭性胸腺瘤有高表达，可能成为临床诊断与鉴别侵袭性胸腺瘤的较为有效的分子学评价指标，二者结合应用可能对诊断具有更高的应用价值。
Objective To analyze the Axin and beta-catenin expression in invasive thymoma,in order to provide a basis for guiding the clinical diagnosis,treatment and prognosis. Methods From Jan-uary 2013 to October 2014,112 patients with thymoma were divided into non invasive group（stage Ⅰ, 52 cases）and invasive group（stage Ⅱ - Ⅳ,60 cases）according to staging Masaoka packet,including 52 cases of stage Ⅱ,6 cases of stage Ⅲ,2 cases of phase Ⅳ. Tissue samples were detected by immuno-histochemical method,Axin and beta-catenin positive cases were compared. Results The positive ex-pression of Axin in invasive thymoma rate was 93. 3%（56 / 60）,which was significantly higher than that of non invasive thymoma in 57. 7%（30 / 52）,the data between the two groups had significant difference （χ2 = 10. 692,P ﹤ 0. 01）;invasive thymoma patients,the positive expression rate of Axin in stage Ⅱwas 50%（26 / 52）,in stage Ⅲ was 66. 7%（4 / 6）,in stage Ⅳ was 100%（2 / 2）,there were no signif-icant differences in data among the three groups（χ2 = 2. 411,P ﹥ 0. 05）. Beta-catenin positive expres-sion rate of invasive thymoma was 93. 3%（56 / 60）,which was significantly higher than that of non inva-sive thymoma in 57. 7%（30 / 52）,there was significant difference between the two groups（χ2 = 1. 852, P ﹤ 0. 01）;invasive thymoma,beta-catenin positive expression rate of phase in stage Ⅲ was 100%（6 / 6）,in stage Ⅳ was 100%（2 / 2）,in stage Ⅱ was 92. 3%（48 / 52）,the data among the three groups had significantly differents（χ2 = 15. 070,P ﹤ 0. 01）. Conclusions Axin and beta-catenin in in-vasive thymoma patients than in non invasive thymoma with high expression,may be the molecular evalu-ation index is more effective clinical diagnosis and differential diagnosis of invasive thymoma,the combi-nation of the two application may have a higher value for the diagnosis.
出处
《中国实用医刊》
2016年第4期3-5,共3页
Chinese Journal of Practical Medicine
