摘要
目的分析研究尤瑞克林联合低分子右旋糖酐治疗急性脑梗死的临床疗效及安全性。方法将87例急性脑梗死患者按照治疗方式的不同分为观察组47例和对照组40例,两组均给予抗血小板聚集、控制血压等常规治疗,观察组在此基础上给予尤瑞克林联合低分子右旋糖酐治疗,对照组仅给予低分子右旋糖酐治疗,疗程14天,观察两组患者治疗前及治疗后14天神经功能缺损程度、临床疗效及不良反应情况。结果观察组总有效率达93.61%,对照组总有效率达82.50%,观察组临床疗效明显优于对照组(P<0.05);观察组及对照组治疗后ADL评分均较治疗前明显提高,且观察组较对照组提高更显著(P<0.05);治疗14 d天后,观察组和对照组NIHSS评分均较治疗前明显降低,且观察组NIHSS评分较对照组降低更明显(P<0.05)。结论尤瑞克林联合低分子右旋糖酐用于治疗急性脑梗死安全、临床疗效肯定且改善预后明显。
Objective To analyze clinical efficacy and safety of urinary kallidinogenase combined low molecular dextran for treatment of acute cerebral infarction. Methods 87 patients with acute cerebral infarction were divided into an observation group（ n = 47） and a control group（ n = 40） according to different treatments. All patients were given conventional treatment to prevent platelet aggregation and control blood pressure. Based on the conventional treatment,patients in the observation group were treated with urinary kallidinogenase combined low molecular dextran,while those in the control group were treated with low molecular dextran alone,for 14 days. Neurological deficits,clinical efficacy and adverse reactions were observed in two groups of patients before treatment and at 14 days after treatment. Results The overall effective rate was 93. 61% in the observation group and 82. 50% in the control group,clinical efficacy of the observation group was obviously better than the control group（ P〈0. 05）. Activity of daily living scale scores in both observation group and control group were significantly improved after treatment,and the improvement was more significant in the observation group（ P〈0. 05）. at 14 days after treatment,NIHSS score in the observation and control groups was significantly decreased after treatment,and the decline was more obvious in the observation group than in the control group（ P〈0. 05）. Conclusions Urinary kallidinogenase combined low molecular dextran is a safe,effective treatment of acute cerebral infarction,and can obviously improve the prognosis.
出处
《航空航天医学杂志》
2016年第3期293-294,共2页
Journal of Aerospace medicine
关键词
脑梗死
急性
尤瑞克林
低分子右旋糖酐
cerebral infarction
acute
urinary kallidinogenase
low molecular dextran
