摘要
背景先天性眼球震颤患者的眼球运动波形表现各异，其时间动力学的非线性特征复杂，常规的时间序列波形图不便于对患者进行临床诊断及评估。眼球运动系统是非线性反馈控制系统，而相图法是一种用于描绘非线性系统运动特征的分析技术，但相图法在先天性眼球震颤检测中的应用尚未见报道。目的尝试建立先天性眼球震颤眼球运动波形的相图法分析技术，为先天性眼球震颤的临床诊断与定量评估提供新的方法。方法采用前瞻性病例观察设计，纳入2012年4月至2013年2月在天津市眼科医院就诊的25例先天性眼球震颤患者，其中先天性运动性眼球震颤（CMN）患者12例，隐性眼球震颤（LN）患者13例。所有患者行视频眼动图（VOG）检查，对VOG数据进行格式转换后，采用Matlab程序对数据进行处理，得到每个眼动波形周期的相位图，并从相位图上测得周期位移（CPS）、慢相峰值速度（SPV）及其标准化值（SSPV）、快相峰值速度（FPV）及其标准化值（SFPV）。比较先天性眼球震颤波形速度递增型和速度递减型的测量参数。结果先天性眼球震颤的眼球运动相图呈现周期性规律性往复运动轨迹，其慢相过程表现为密集带状轨迹，快相过程表现为稀疏环状轨迹。CMN的眼球运动波形以速度递增型为主，而LN的眼球运动波形以速度递减型为主，2种波形相图轨迹走行均呈顺时针方向。速度递增型CPS、SPV及FPV分别为（4．646±1．565）、（223．821±114．049）和（767．481±263．560）°／s，速度递减型CPS、SPV及FPV分别为（9．373±4．189）、（357．531±154．300）和（1148．706±541．362）°／s；速度递增型中SPV和FPV与CPS间均呈显著正相关（rFPV-CPS=0．685，P=0．000；rFPV-CPS=0．680，P=0．000）；速度递减型中SPV和FPV与CPS间均呈显著正相关（rFPV-CPS＝0.783，s=0．783，P=0．000；rFPV-CPS=0．803
Background The characteristics of eye movement waveforms in congenital nystagmus eyes is so complicated that the time-series waveform can hardly demonstrate the oscillational kinetic property of the eyemovement of nystagmus,which is not convenient for the clinical diagnosis and evaluation. The eye movement system is a nonlinear feedback control system, and phase portrait analysis is a useful method in describing the characteristics of movement in a nonlinear system. Objective This study was to establish the phase portrait analysis method of the eye movement waveforms in congenital nystagmus eyes and provide a new technique for the clinical diagnosis and evaluation of congenital nystagmus. Methods A prospective series-case observational study was performed. This study complied with the Declaration of Helsinki and was approved by Ethic Commission of Tianjin Eye Hospital. Written informed consent was obtained from each patient before examination. Twenty-five patients with congenital nystagmus were enrolled and received examination of video-oculography （VOG） in Tianjin Eye Hospital from April 2012 to February 2013,including 12 patients with congenital motor nystagmus （CMN） and 13 patients with latent nystagmus （LN）. The VOG data were format-converted and processed by a Matlab routine. VOG-based phase portraits of eye movement cycles were drawn and related parameters were measured from the phase portraits for further analysis and comparison. Main measurement indexes were cycle position shift （CPS）, slow phase peak velocity （SPV）, standardized slow-phase peak （SSPV）, fast phase peak velocity （FPV） and standardized fast-phase peak velocity （SFPV）. Two principal types of waveforms,increasing-velocity type and decreasing-velocity type were compared. Results The phase portraits of the waveforms of congenital nystagmus were cycles of reciprocating trajectories. The slow phases were in dense ribbon region, and the fast phases were in sparse annular region, and all the trajectories travelled in
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2016年第4期330-334,共5页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金重点项目（30730099）
国家自然科学基金面上项目（81371049）
国家自然科学基金青年项目（81100694）
天津市自然科学基金项目（11JCYBJC12700）
天津市卫生局科技项目（2010KY16）
关键词
先天性眼球震颤/诊断
病理性眼球震颤/先天性
运动觉
眼球运动测定
相图
视频眼
动图
眼扫视
人
Nystagmus, congenital/diagnosis
Nystagmus, pathologic/congenital
Motion perception
Eye movement measurements
Phase portrait
Video-oculography
Saccades
Humans
