摘要
背景:以磷酸钙和硫酸钙为主要成分,复合其他一种或多种材料来改善或增加骨组织工程支架性能是目前的研究热点。目的:介绍两种支架在组织工程中的研究进展。方法:以"骨组织工程,复合支架,磷酸钙,硫酸钙,血管化;bone tissue engineering、composite scaffold,calcium phosphate,calcium sulphate,vascularization"为检索词,应用计算机分别在检索中国期刊全文数据库和Pub Med数据库检索2000年1月至2015年6月与骨组织工程相关的文章。结果与结论:磷酸钙和硫酸钙具备良好的生物相容性、可降解性、骨传导性和完全骨替代性等特性,但单一成分的磷酸钙及硫酸钙均存在一定的缺点,难以完全满足骨缺损修复的要求,通过与不同材料复合,可改进支架的机械强度、可注射性、降解性,优化载药性能和促血管生成等,在基础与临床研究中,应根据治疗的目的来开发理想支架材料。目前绝大多数支架材料还处于体外试验和动物实验阶段,关于不同复合型支架材料的对比研究、复合支架的最佳配比等方面仍待进一步深入研究。
BACKGROUND： It is a hotspot that calcium phosphate and calcium sulphate as the main ingredients are combined with one or more other materials to improve or increase the performance of bone tissue engineering scaffolds. OBJECTIVE： To introduce the research advance of these two kinds of scaffolds in bone tissue engineering. METHODS： The articles related to the bone tissue engineering published during January 2000 to June 2015 were retrieved from CNKI and Pub Med databases by computer. The key words were ＂bone tissue engineering, scaffold, calcium phosphate, calcium sulphate, vascularization＂ in Chinese and English, respectively. ESULTS AND CONCLUSION： Calcium phosphate and calcium sulfate are characterized as having good biocompatibility, biodegradability, osteoconductivity and complete bone substitutability. However, single use of calcium phosphate or calcium sulfate scaffold has certain disadvantages, both of which are difficult to fully meet the requirements of the bone defect repair. Improvement can be acquired in the mechanical strength, injectability and biodegradability, as well as drug-loading and pro-angiogenesis of the scaffold in combination with other materials. In the basal and clinical research, we should explore and develop ideal scaffolds in on the basis of therapeutic aim. However, most of the scaffold studies are still at the extracorporeal and animal experiment stage, and the comparative studies on composite scaffolds and optimal proportion of those composite scaffolds still need to be further investigated.
出处
《中国组织工程研究》
CAS
北大核心
2016年第8期1203-1209,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81503591)
广东省科学技术厅-广东省中医药科学院联合科研项目(2014A020221021)
广东省自然科学基金(2014A030310082)
广东省教育厅学科建设专项基金(育亩工程)[2013LYM-0012]
广州中医药大学优秀青年学者科研基金(KAB110133K04)
广州中医药大学第一临床优博论文培育项目(YB201501)~~
