摘要
目的了解聚普瑞锌对功能性消化不良患者临床疗效的影响。方法将20例功能性消化不良患者按数字表法随机分为两组，每组10例，均予以泮托拉唑肠溶片＋阿米替林＋盐酸帕罗西汀治疗，在此基础上观察组予以聚普瑞锌治疗，对照组予以枸橼酸莫沙比利治疗，观察12周。于治疗前后采用9条目患者健康问卷评定抑郁状况，治疗12周末根据临床症状改善状况评定临床疗效。结果治疗后观察组显效率为70％、总有效率为90％，对照组分别为30％、80％，观察组均高于对照组，但差异无显著性（P〉0．05）。治疗后观察组抑郁情绪检出率由100％降为30％，对照组由90％降为70％，同期两组间比较差异无显著性（P〉0.05）。结论对功能性消化不良患者在常规治疗的基础上，联合聚普瑞锌治疗能有效降低抑郁情绪发生率，进一步提高临床疗效。
Objective To investigate the effectiveness of polaprezinc in the treatment of functional dyspepsia （FD）. Methods Twenty FD patients were assigned to two groups of 10 ones each sccording to random number table, both groups were treated with pantoprazole enteric-coated tablets＋amitriptyline＋ paroxetine hydrochloride, on this basis observation group was plus polaprezinc and control group mosapride citrate tablets for 12 weeks, Depressed states were assessed with the Patient Health Questionnaire （PHQ-9） before and after treatment and efficacies according to the improvement of clinical symptoms at the end of the 12th week. Results After treatment the obvious and total effective rate were respectively 70% and 90% in observation and 30% and 80% in control the former were higher than the latter, but differences weren＇t significant （P〉0. 05）. After treatment the detection rate of depression lowered from 100% to 30% in observation and from 90% to 70% in control group, contemporaneous group comparisons showed no significant differences （P 〉 0. 05）. Conclusion Routine treatment plus polaprezinc could effectively lower the incidence of depression and further boost effectiveness in ED.
出处
《临床心身疾病杂志》
CAS
2016年第2期115-116,共2页
Journal of Clinical Psychosomatic Diseases
