摘要
目的观察地佐辛复合丙泊酚应用于无痛取卵手术时的麻醉效果及对呼吸的影响。方法 130例行无痛取卵术患者随机分为地佐辛组和芬太尼组,分别复合丙泊酚静脉麻醉,观察麻醉前、手术时、苏醒时的心率、脉搏氧饱和度（SPO_2）、心率（HR）、平均动脉压（MAP）变化;观察体动例数、苏醒时间、疼痛数字评分（NRS）、Ramsay评分及呼吸抑制、头痛头晕、恶心呕吐及嗜睡等不良反应发生情况。结果两组患者麻醉前、手术时、苏醒时SPO_2、HR、MAP组间比较,差异均无统计学意义（t分别=1.28、-0.55、0.46、2.18、2.21、2.18、1.29、1.99、-0.16,P均〉0.05）。地佐辛组患者手术时体动例数、苏醒时间、NRS评分、Ramsay评分与芬太尼组相比,差异均无统计学意义（χ^2=0.99,t分别=-0.82、0.43、-2.01,P均〉0.05）,但呼吸抑制及恶心呕吐的发生率明显少于芬太尼组,差异均有统计学意义（χ^2分别=6.93、5.20,P均〈0.05）。结论地佐辛应用于无痛取卵手术的麻醉效果确切,术中血流动力学稳定,不良反应的发生率低,对呼吸的抑制作用轻,临床应用安全、有效。
Objective To observe the anesthesia effect and the influence to respiration of dezocine combined with propofol in painless ova surgery. Methods A total of 130 patients with painless oocyte retrieval were randomly divided into dezocine group and fentanyl group with 65 cases in each. The two groups were all given propofol intravenous anesthesia.The changes of heart rate（HR）, pulse oxygen saturation（SPO_2） and mean arterial pressure（MAP） were recorded before anesthesia, during surgery and revival were observed. The body motions, recovery time, NRS score, Ramsay score and adverse reactions such as respiratory depression, headache, dizziness, nausea, vomiting, drowsiness were recorded. Results The SPO_2、HR、MAP before anesthesia, during surgery and revival between two groups was not statistically different（t=1.28,-0.55, 0.46, 2.18, 2.21, 2.18, 1.29, 1.99,-0.16, P〉0.05）. There was no statistical difference of body motions,recovery time, NRS score, Ramsay score between two groups（χ~2=0.99,t=-0.82, 0.43,-2.01,P〉0.05）. The incidence of respiratory depression and nausea and vomiting of dezocine group were significantly lower than fentanyl group（χ~2=6.93,5.20,P〈0.05）. Conclusion The anesthesia effect of dezocine is obvious, safe and effective because of stable hemodynamics,lower incidence of adverse reaction and slight respiration inhibitory.
出处
《全科医学临床与教育》
2016年第2期183-185,共3页
Clinical Education of General Practice
关键词
地佐辛
丙泊酚
芬太尼
无痛取卵术
dezocine
propofol
fentanyl
painless oocyte retrieval
