摘要
目的分析2011~2013年安徽省黄山市多家医院抗微生物药品不良反应（ADR）报告并总结其数据特点,以减少药品不良反应的发生,促进临床安全、合理用药。方法收集安徽省黄山市2011~2013年抗微生物ADR报告1 055例,利用药品不良反应综合分析系统（ADRCAS）,将报告数据按患者年龄、性别、涉及药品种类、给药途径等方面进行分析。结果 2011~2013年黄山市抗微生物药品引起ADR发生最多的年龄在40~〈50岁[22.27%（235/1 055）];累及器官或系统最多的为胃肠道系统[36.21%（382/1 055）],其次为皮肤及其附件[23.22%（245/1 055）];阿莫西林、阿奇霉素和罗红霉素的ADR发生率最高,分别为26.59%（271/1 055）、19.53%（206/1 055）、16.49%（174/1 055）。结论临床在使用抗微生物类药物治疗的过程中,既要关注药物对患者病情的治疗效果,也要高度警惕该类药物ADR所带来的危害性,注重临床用药的安全性及合理性。
Objective To analyze the reports of adverse drug reactions（ADR） caused by anti-microbacterial drugs from multiple hospitals in Huangshan City of Anhui Province during 2011-2013 and to summarize the data characteristics in order to reduce the ADR occurrence and promote the clinical safe and rational use of drugs. Methods A total of 1 055 cases of ADR report were collected in Huangshan City during 2011-2013. By using the ADR comprehensive analysis system（ADRCAS）,the report data were analyzed in the aspects of the age,gender,type of involved drug and drug delivery route. Results Most of ADR caused by antimicrobial drugs in Huangshan City during 2011-2013 occurred in the age period of 40-〈50 years old[22.27%（235/1 055）],most of involved organs or systems were the gastrointestinal tract system was[36.21%（382/1 055）],followed by skin and its accessories[23.22%（245/1 055）];amoxillin,azithromycin and roxithromycin had the highest ADR occurrence rate,which were 26.59%（271/1 055）,19.53%（206/1 055） and 16.49%（174/1 055）respectively. Conclusion In the clinical treatment process of antimicrobial drugs,the treatment effects should be paid high attention to,also their caused ADR should be highly alert, paying attention to safety and rationality of clinical medication.
出处
《现代医药卫生》
2016年第7期978-980,共3页
Journal of Modern Medicine & Health
基金
2014年皖南医学院大学生科研资助项目(WK2014S20)
关键词
抗菌药/副作用
药物利用
药物副反应报告系统
药物监测
给药系统
药用制剂/副作用
Anti-bacterial agents/adverse effects
Drug utilization
Adverse drug reaction reporting systems
Drug monitoring
Medication systems
Pharmaceutical preparations/adverse effects
