摘要
目的探讨胱抑素C(Cys C)、纤维蛋白原(Fbg)浓度和24h尿蛋白定量与紫癜性肾炎(HSPN)患儿肾脏病理分级的相关性和应用价值。方法收集2011年1月至2015年1月48例经肾活检明确诊断为HSPN患儿的病历资料,根据肾脏病理结果分为Ⅱa级及Ⅱa级以下12例、Ⅱb级12例、Ⅲa级17例及Ⅲb级及Ⅲb级以上7例。乳胶增强散射免疫比浊法检测所有患儿血清Cys C,浊度法检测Fbg浓度,终点法检测24h尿蛋白定量水平;采用Pearson和Spearman相关分析对各检测指标之间及各指标与肾脏病理分级之间进行相关分析。结果血清Cys C、Fbg浓度和24h尿蛋白定量在各肾脏病理分级患儿中比较差异均有统计学意义(P<0.05),且各指标水平均随病理分级严重程度增高而上升(P<0.05)。48例HSPN患儿血清Cys C和Fbg与24h尿蛋白定量之间均呈正相关(分别r=0.51、0.63,P<0.05);Fbg与血清Cys C之间呈正相关(r=0.55,P<0.05);Cys C、Fbg及24h尿蛋白定量与肾脏病理分级之间均呈正相关(分别r=0.66、0.64、0.68,均P<0.05)。结论 Cys C、Fbg和24h尿蛋白定量均能反映肾脏损伤严重程度,对于HSPN患儿肾脏损伤的严重程度具有较好的判断作用。
Objective To study the relationship of cystatin C（Cys C）, fibrinogen（Fbg）, and 24-hour urinary protein with renal pathological grade in children with Henoch-Sch？nlein purpura nephritis（HSPN）, and to explore their values. Methods The clinical data of 48 children diagnosed with HSPN by renal biopsy from January 2011 to January 2015 were reviewed. According to renal pathological grading, in the 48 children with HSPN, 12 had stage IIa or lower, 12 stage IIb, 17 stage IIIa, and 7 stage IIIb or higher. The latex-enhanced immunoturbidimetric assay, turbidimetric measurement, and end-point method were used to determine the levels of serum Cys C, Fbg, and 24-hour urinary protein, respectively. Pearson and Spearman correlation analyses were used to test the correlations between the indices and between the indices and renal pathological grade. Results There were significant differences in the levels of serum Cys C, Fbg, and 24-hour urinary protein between patients with different pathological grades（P〈0.05）. The level of each index increased with increasing pathological grade（P〈0.05）. In the 48 children with HSPN, the level of 24-hour urine protein was positively correlated with the levels of serum Cys C（r=0.51, P〈0.05） and Fbg（r=0.63, P〈0.05）. The level of Fbg was positively correlated with that of serum Cys C（r=0.55, P〈0.05）. The levels of Cys C, Fbg, and 24-hour urinary protein were all positively correlated with renal pathological grade（r=0.66, 0.64 and 0.68; respectively, P〈0.05）. Conclusions The levels of Cys C, Fbg, and 24-hour urine protein can reflect the severity of renal injury, providing satisfactory prediction of the severity of renal injury in children with HSPN.
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2016年第3期233-237,共5页
Chinese Journal of Contemporary Pediatrics
关键词
胱抑素C
纤维蛋白原
尿蛋白定量
紫癜性肾炎
儿童
Cystatin C
Fibrinogen
24-Hour urinary protein
Henoch-Schonlein purpura nephritis
Child
