摘要
目的研究慢性乙型肝炎及乙肝肝硬化合并消化性溃疡患者与幽门螺杆菌(Helicobacter pylori,H.pylori)感染的相关关系。方法选择2012年1月至2014年12月宣汉县人民医院收治的慢性乙型肝炎合并消化性溃疡患者108例作为A组,选择同期收治的乙肝肝硬化合并消化性溃疡患者65例作为B组。以快速尿素酶方法检测H.pylori。应用免疫印迹法急性H.pylori抗体分型。结果 A组患者H.pylori阳性率为67.6%,B组患者H.pylori阳性率为24.6%。A组胃溃疡患者H.pylori阳性率为11.4%,十二指肠溃疡患者H.pylori阳性率为94.5%;B组胃溃疡患者H.pylori阳性率为11.5%,十二指肠溃疡患者H.pylori阳性率为33.3%。A组及B组患者中十二指肠溃疡H.pylori感染率均显著高于胃溃疡H.pylori感染率(P<0.05)。两组胃溃疡患者的H.pylori阳性率比较差异无统计学意义(P>0.05),十二指肠患者的H.pylori阳性率在A、B两组间差异有统计学意义(χ2=48.528,P<0.01)。两组患者H.pylori抗体血清分型表达阳性率比较差异无统计学意义(χ2=0.464,P>0.05)。结论 H.pylori感染可能是慢性乙肝、乙肝肝硬化消化性溃疡发生的始动因素,尤其在慢性乙肝合并十二指肠溃疡的发病中可能起重要作用,在乙肝肝硬化合并十二指肠溃疡疾病的发病中可能只是其中因素之一。
Objective To study the correlation between chronic hepatitis/liver cirrhosis and Helicobacter pylori（H.pylori）infection in patients with peptic ulcer.Methods 108 peptic ulcer patients with chronic hepatitis in our hospital from January 2012 to December 2014 were included as the group A,while 65 peptic ulcer patients with liver cirrhosis included as the group B.H.pylori was detected with Rapid urease method.H.pylori antibody typing were done with immunoblotting.Results The positive rate of H.pylori was 67.6%in group A and 24.6%in Group B.In group A,the positive rate of H.pylori was 11.4%in patients with gastric ulcer and 94.5% in patients with duodenal ulcer,while in group B,the positive rate was 11.5%in patients with gastric ulcer and 33.3%in those with duodenal ulcer.The H.pylori infection rates in patients with duodenal ulcer were significantly higher than in those with gastric ulcer in both Group A and B（P〈0.05）;the difference between the two groups was not statistically significant in patients with gastric ulcer（P〈0.05）,but in patients with duodenal ulcer（χ2=48.528,P〈0.01）.The serotypes of H.pylori antibody expression were not statistically different between the two groups（χ2=0.811,P〈0.05）.Conclusion H.pyloriinfection may be the initial factor in chronic hepatitis and liver cirrhosis with peptic ulcer,which may play an important role in the pathogenesis of chronic hepatitis B combined duodenal ulcer especially,while in liver cirrhosis may be just one of the factors associated with the incidence of duodenal ulcer.
出处
《中国微生态学杂志》
CAS
CSCD
2016年第4期446-449,共4页
Chinese Journal of Microecology
