摘要
目的:制备染料木素固体分散体,以提高其体外溶出度。方法:分别以聚乙烯吡咯烷酮K30(PVP K30)、聚乙二醇(PEG)6000、PEG4000为载体,采用溶剂-熔融法制备染料木素固体分散体,考察其体外溶出度,并采用傅里叶红外光谱法(FTIR)、差示扫描量热法(DSC)对固体分散体的结构特征进行分析。结果:以PEG4000为载体制备的染料木素固体分散体的体外溶出度优于其他载体制备的固体分散体,且以药物-载体比例1∶5为最佳。DSC与FTIR测定结果表明,固体分散体中染料木素以非晶形式存在。结论:成功制得染料木素固体分散体,其可显著提高染料木素的体外溶出度。
OBJECTIVE：To prepare Geinstein（GEN） solid dispersion,and improve the dissolution rate of GEN in vitro.METHODS：Using PVP K30,PEG6000,and PEG4000 as carriers,GEN solid dispersion was prepared by solvent melting method,and its dissolution in vitro was investigated. The structure of the solid dispersion was characterized by FTIR and DSC. RESULTS：GEN solid dispersion prepared with PEG4000 as carrier was better than those with other carriers in dissolution,and drug-carrier ratio（1 ∶ 5） was the best. The results of DSC and FTIR showed that GEN in solid dispersion took amorphous form.CONCLUSIONS：GEN solid dispersion is prepared successfully and significantly improve the dissolution of GEN in vitro.
出处
《中国药房》
CAS
北大核心
2016年第10期1406-1408,共3页
China Pharmacy
