摘要
目的 探讨烟酸缺乏症的病因、发病机制、实验室检查、脑电图特点、治疗及预后。方法 收集本院2004年至2014年的34例诊断为烟酸缺乏症和1例合并亚急性联合变性的烟酸缺乏症的患者病例资料,对其临床资料进行分析。结果 本病男女比例1：2,病因多种多样,主要临床表现为“4D综合征”,即皮炎,腹泻,痴呆及死亡,给予补充烟酸等综合处理后,皮肤损害多在15-25d较前明显好转。结论 烟酸缺乏严重者可继发周围及中枢神经损害,可合并亚急性脊髓联合变性,早期给予烟酸治疗可改善预后。
Objective To explore the pathogeny, pathogenesis, laboratory examination, EEG characters, therapy and prognosis of niacin deficiency. Methods Collecting 34 cases diagnosed of niacin deficiency in recent 10 years in our hospital and 1 case considered niacin deficiency with subacute combined degeneration of spinal cord lately, we took the retrospective analysis with the clinical data. Results The proportion of male and female was 1 ： 2 in niacin deficiency. The pathogeny of niacin deficiency was multifarious , the main clinical manifestations was ＂4D syndrome＂, that was dermatitis, diarrhea, dementia and death, and the lesions recovered in 15-25 days after the symptomatic treatment of niacin intaked. Conclusion Severe niacin deficiency can secondary to peripheral and central nerve damage, even combined with subacute combined degeneration of spinal cord. Early niacin intaked and treatment can improve the prognosis.
出处
《脑与神经疾病杂志》
2016年第4期240-247,共8页
Journal of Brain and Nervous Diseases
关键词
烟酸缺乏
脊髓亚急性联合变性
皮炎
舌炎
Niacin deficiency
Subacute combined degeneration of spinal cord
Dermatitis
Glossitis
