摘要
研究表明神经退行性病在卵巢功能下降后明显增加。雌激素替代疗法能降低神经退行性疾病的危险因素,改善其严重程度;能维持神经元细胞膜脂质的稳定性,增强神经元的抗氧化作用,抑制β淀粉样蛋白(amyloid beta protein,Aβ)的沉积,减少对神经毒性物质的重吸收,发挥其对神经细胞的保护作用。而SH2-B(Src homology 2)作为细胞内的一种连接蛋白,介导神经生长因子的信号转导。SH2-Bβ减缓由缺少神经生长因子所引发的神经退化现象,并且促进神经再生。用Aβ刺激PC12细胞作为神经细胞损伤模型来研究雌激素在发挥神经元保护作用的过程中与SH2-Bβ的关系,为神经退行性疾病的治疗提供理论基础。
Many studies indicated that neurodegeneratiove diseases increased significantly after ovarian function decline. Estrogen replacement therapy can reduce the risk factors in neuronal degeneration,improve its severity. It can maintain the stability of neuronal cell membrane lipid,enhance the antioxidant function of neurons,inhibiting beta amyloid（ Aβ） protein deposition,reduce the absorption of heavy against neurotoxic substances,exert its protective effect on neural cells. And SH2-B as the connection of intracellular protein A,mediated by nerve growth factor（ NGF） signal transduction. SH2-B beta neural degeneration phenomenon caused by lack of nerve growth factor,and promote nerve regeneration. Nerve cell injury model was found through Aβ stimulating PC 12 cell to study neuroprotective effects of estrogen and relation with SH2-B beta,and to provide the theory basis for the treatment of the neuro degenerative diseases.
出处
《沈阳医学院学报》
2016年第1期48-50,共3页
Journal of Shenyang Medical College
基金
辽宁省大学生创新创业训练计划项目(No.201410164000001)
沈阳医学院大学生基金项目(No.20141018)
沈阳医学院科技基金项目(No.20141019)
