摘要
蓝萼甲素(glaucocalyxin A,GLA)是一种具有对映15-氧-16贝壳杉烯(ent-15-oxo-16-kaurene)骨架结构的二萜类化合物。其具有心血管保护、内皮保护、抗凝血、抗乙肝病毒、抗肿瘤、抑菌、抗炎、耐缺氧、免疫抑制及调节钙离子浓度等多种药理作用,并且有很高的体内安全性。民间常用蓝萼香茶菜治疗肝炎、胃炎、乳腺炎、腹痛、关节痛等疾病,临床上蓝萼香茶菜主要用于治疗冠心病、心绞痛、脑供血不足等缺血、缺氧性心脑血管疾病。本研究将对蓝萼甲素的药理作用及其机制和毒理学作用做一总结。
Glaucocalyxin A（GLA）is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene.It has various pharmacological activities,such as cardiovascular and endothelium cellular protection,anti-blood coagulation,anti-Hepatitis B Virus（HBV）,anti-tumor,anti-bacteria,anti-inflammation,hypoxic tolerance,immunomodulation and Ca2＋concentration regulation effect,where as its in vivo safety is quite good.As a folk medicine,it is conventionally used to treat hepatitis,gastritis,mastitis,stomachache and arthralgia.It is also used for ischemic and/or hypoxic cardio-cerebrovascular diseases such as coronary heart diseases,stenocardia and chronic cerebral circulation insufficiency in clinic.This review gives a summary of the pharmacological effects,biological mechanism,and toxicity of Glaucocalyxin A.
出处
《药学实践杂志》
CAS
2016年第2期124-128,共5页
Journal of Pharmaceutical Practice
关键词
蓝萼甲素
香茶菜
药理作用
毒理作用
Glaucocalyxin A
Rabdosia（BI.）Hassk
pharmacological activity
toxicology
