摘要
目的 探讨肝动脉化疗栓塞（TACE）联合栓塞肿瘤肝外侧支动脉治疗原发性肝癌（HCC）的临床疗效。方法 回顾性分析79例原发肝癌介入治疗,其中采用TACE联合栓塞肿瘤肝外侧支动脉40例（A组）,只接受单纯肝动脉TACE 39例（B组）,两组临床资料差异无统计学意义。对比观察两组患者近期甲胎蛋白（AFP）及肿瘤变化,随访生存时间。统计学分析采用PASWl 8.0统计软件,计量资料以“x±s”表示,手术前后数据之间的差异采用配对t检验;采用Kaplan-Meier计算中位生存期;P〈0.05为差异有统计学意义。结果 A、B两组6个月时AFP下降（例）27/32对比20/33,χ~2=4.580,P=0.039。肿瘤治疗后3个月及6个月时反应（CR＋PR＋SD）情况为35/40对比32/39,χ~2=0.458,P=0.518;32/38对比23/37,χ~2=4.653,P=0.029。两组患者术后生存时间,A组为6~56个月,平均（24.85±11.68）个月,B组为6~48个月,平均（17.46±6.56）个月,t=3.048,P=0.004。结论TACE联合栓塞肿瘤肝外侧支动脉较单纯肝动脉TACE疗效明显优,肝外侧支动脉是影响原发性肝癌介入治疗的重要因素,采取规范、综合措施,积极预防、治疗原发性肝癌肝外侧支动脉,可提高原发性肝癌中远期疗效。
Objective To evaluate hepatic arterial chemoembolization （TACE） combined with extrahepatic collateral arterial embolization of tumor therapeutic effect of hepatocellular carcinoma （HCC）. Methods Retrospective analysis of 79 cases of HCC in interventional therapy, one using TACE combined with extrahepatic collateral artery embolization tumor with 40 cases （ A group）, another only accept simple hepatic artery TACE with 39 patients （ group B）. The two groups showed no significant difference in clinical data. Comparison in fetoprotein were observed recently （AFP） , tumor change, follow-up survival time. PASW18.0 statistical analysis using statistical software, measurement data＂x ＋ s＂ represents the difference between the data before and after surgery using paired t test; calculated using the Kaplan-Meier median survival time ; difference P 〈 0.05 as statistically Significance. Results A, B two had 6-month decline AFP （Example） Comparative groud A ：27/32 vs. groud B ：20/33, X^2 = 4. 580, P = 0. 039. After cancer treatment three months and six month response （ CR ＋ PR ＋ SD） Comparative case groud A ：35/40 vs. groud B ： 32/39, X^2 = 0.458, P = 0.518 ; 32/38 vs. 23/ 37, X^2 = 4. 653, P =0. 029. The postoperative survival time, A group of 6 to 56 months, average （24.85 ＋ 11.68 ） months, group B of 6 to48 months, average （17.46±6.56） months, t=3.048,P=0.004. Conclusion TACE com- bined with extrahepatic collateral artery embolization tumor efficacy of TACE is significantly better than the simple hepatic artery, hepatic artery outside of the impact are the important factors involved in the treatment of primary liver cancer. Take standardized, comprehensive measures to actively prevent and treat primary liver cancer, extrabepatic collateral arteries im- prove the long-term effect of primary liver cancer.
出处
《临床放射学杂志》
CSCD
北大核心
2016年第3期453-457,共5页
Journal of Clinical Radiology
关键词
原发性肝癌
化疗栓塞术
肝外侧支循环
疗效分析
Primary hepatoceilutar carcinoma Chemoembolization Extrahepatic collateral circulation Effect analysis
